TY - JOUR
T1 - Gender, alcohol consumption, and renal cell carcinoma
AU - Parker, Alexander S.
AU - Cerhan, James R.
AU - Lynch, Charles F.
AU - Ershow, Abby G.
AU - Cantor, Kenneth P.
N1 - Funding Information:
Supported by National Cancer Institute contracts NCI-NO1-CP-5106 and NCI-NO1-CP-85614. Dr. James R. Cerhan was supported in part by a National Cancer Institute Preventive Oncology Academic Award.
PY - 2002/3/1
Y1 - 2002/3/1
N2 - The nature of the association between alcohol consumption and renal cell carcinoma (RCC) is not well understood, but there are indications of effect modification by gender. The authors report data from a population-based case-control study conducted in Iowa from 1986 to 1989. RCC cases (261 men and 145 women) were identified through the Iowa Cancer Registry, while controls (1,598 men and 831 women) were randomly selected from the general population, frequency matched on age and gender. Subjects provided detailed information on a mailed questionnaire regarding demographic, anthropometric, lifestyle, dietary, and medical history risk factors. In age-adjusted analysis, there was a decrease in risk for women who reported consuming more than three servings (median among drinkers) of alcohol per week (odds ratio = 0.5, 95% confidence interval: 0.2, 0.9) compared with never drinkers. No evidence of an association among men was noted (odds ratio = 1.1, 95% confidence interval: 0.8, 1.5). Multivariate adjustment for anthropometric, lifestyle, smoking, and dietary factors did not alter the findings. Analysis by type of alcohol suggested that the inverse association was strongest for beer consumption, but estimates were imprecise. These findings suggest an inverse association of alcohol consumption and RCC development among women but not among men.
AB - The nature of the association between alcohol consumption and renal cell carcinoma (RCC) is not well understood, but there are indications of effect modification by gender. The authors report data from a population-based case-control study conducted in Iowa from 1986 to 1989. RCC cases (261 men and 145 women) were identified through the Iowa Cancer Registry, while controls (1,598 men and 831 women) were randomly selected from the general population, frequency matched on age and gender. Subjects provided detailed information on a mailed questionnaire regarding demographic, anthropometric, lifestyle, dietary, and medical history risk factors. In age-adjusted analysis, there was a decrease in risk for women who reported consuming more than three servings (median among drinkers) of alcohol per week (odds ratio = 0.5, 95% confidence interval: 0.2, 0.9) compared with never drinkers. No evidence of an association among men was noted (odds ratio = 1.1, 95% confidence interval: 0.8, 1.5). Multivariate adjustment for anthropometric, lifestyle, smoking, and dietary factors did not alter the findings. Analysis by type of alcohol suggested that the inverse association was strongest for beer consumption, but estimates were imprecise. These findings suggest an inverse association of alcohol consumption and RCC development among women but not among men.
KW - Alcohol drinking
KW - Carcinoma, renal cell
KW - Case-control studies
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U2 - 10.1093/aje/155.5.455
DO - 10.1093/aje/155.5.455
M3 - Article
C2 - 11867357
AN - SCOPUS:0036498718
SN - 0002-9262
VL - 155
SP - 455
EP - 462
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 5
ER -