Gastroschisis: a systematic review of diagnosis, prognosis and treatment

Rui Gilberto Ferreira, Carolina Rodrigues Mendonça, Lelia Luanne Gonçalves Ramos, Fernanda Sardinha de Abreu Tacon, Waldemar Naves do Amaral, Rodrigo Ruano

Research output: Contribution to journalReview articlepeer-review


Objectives: The present systematic review aims to investigate the diagnosis, prognosis, delivery assistance, pregnancy results and postnatal management in gastroschisis. Study design: The following data sources were evaluated: The CINAHL, Embase and MEDLINE/PubMed databases were searched, observational and intervention studies published over the past 20 years. The quality of the studies was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE). Results: A total of 3770 infants diagnosed with gastroschisis were included (44 studies); 1534 fetuses were classified as simple gastroschisis and 288 as complex gastroschisis. Intrauterine fetal demise occurred in 0.47% and elective termination occurred in 0.13%. Preterm delivery occurred in 23.23% and intrauterine growth restriction in 4.43%. Cesarean section delivery was performed in 54.6%. Neonatal survival was 91.29%. The main neonatal complications were: sepsis (11.78%), necrotizing enterocolitis (2.33%), short bowel syndrome (1.37%), bowel obstruction (0.79%), and volvulus (0.23%). Immediate surgical repair was performed in 80.1% with primary closure in 69%. The average to oral feeding was 33 (range: 11–124.5) days. Average hospital duration was 38 days and 89 days in neonates with simple and complex grastroschisis, respectively. Conclusions: The present systematic review provides scientific data for counseling families with fetal gastroschisis.

Original languageEnglish (US)
Pages (from-to)6199-6212
Number of pages14
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number25
StatePublished - 2022


  • Gastroschisis
  • diagnostic imaging
  • postnatal care
  • prenatal diagnosis
  • prognosis
  • ultrasonography

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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