Gastrointestinal sensation. Mechanisms and relation to functional gastrointestinal disorders

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29 Scopus citations


This article reviews the basic anatomy and physiology of visceral afferent function and its application to a clearer understanding of visceral pain and symptoms in patients with functional gastrointestinal disorders. Recent investigations have focused on the potential role of visceral tone, different afferent (A delta and C) fibers, dorsal column neurons, and supraspinal modulation in the elicitation of visceral perception of noxious and nonnoxious stimuli arising in the gut. Greater understanding of these pathomechanisms and their pharmacologic manipulation offers an opportunity for future therapeutic strategies for these disorders.

Original languageEnglish (US)
Pages (from-to)247-258
Number of pages12
JournalGastroenterology Clinics of North America
Issue number1
StatePublished - 1996

ASJC Scopus subject areas

  • Gastroenterology


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