Gastrointestinal motility disturbances in patients with orthostatic hypotension

Michael Camilleri, Juan R. Malagelada, Vincenzo Stanghellini, Robert D. Fealey, Sheldon G. Sheps

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Orthostatic hypotension syndromes may be associated with visceral denervation, resulting in disturbances of the gastrointestinal and urinary systems. This report analyzes the findings in 9 patients with neurogenic orthostatic hypotension and gastrointestinal symptoms. Antral and proximal small intestinal motor dysfunction was demonstrated in all patients: a significant reduction (p = 0.007) in the number of interdigestive motor complexes during 3 h of fasting (mean 0.4 vs. 1.3 controls); absence of gastric component in interdigestive motor complexes observed; incoordination of fasting and fed antral activity; and development of nonpropagating bursts of phase III-like activity in the intestine that were of at least 2-min duration, high amplitude and frequency, and associated with tonic elevations in baseline pressure. These motor abnormalities may provide a potential means for the diagnosis of impaired autonomic supply to the upper gut.

Original languageEnglish (US)
Pages (from-to)1852-1859
Number of pages8
Issue number6
StatePublished - Jun 1985

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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