Gastrointestinal hormone profile in renal insufficiency.

C. Owyang, L. J. Miller, E. P. DiMagno, L. A. Brennan, V. L. Go

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Fasting serum gastrin, cholecystokinin, glucagon, and gastric inhibitory polypeptide concentrations were simultaneously measured in normal subjects and in patients with different degrees of renal failure. Values of gastrin, cholecystokinin, gastric inhibitory polypeptide, and glucagon were significantly higher in all patients with serum creatinine concentrations greater than 3 mg/dl than in controls (P less than 0.01). The degree of renal insufficiency was significantly correlated (P less than 0.05) with serum concentrations of each hormone, but no significant linear correlation existed among the serum concentrations of different gastrointestinal hormones in individuals. Hemodialysis did not significantly alter predialysis serum gastrin, cholecystokinin, or glucagon concentration, but the serum gastric inhibitory polypeptide concentration decreased by 30% (P less than 0.01) after hemodialysis. The disproportionate increases of hormones with antagonistic actions may alter gastrointestinal function in renal insufficiency.

Original languageEnglish (US)
Pages (from-to)769-773
Number of pages5
JournalMayo Clinic proceedings
Issue number12
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • General Medicine


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