TY - JOUR
T1 - Gastric Sensorimotor Functions and Hormone Profile in Normal Weight, Overweight, and Obese People
AU - Vazquez Roque, Maria I.
AU - Camilleri, Michael
AU - Stephens, Debra A.
AU - Jensen, Michael D.
AU - Burton, Duane D.
AU - Baxter, Kari L.
AU - Zinsmeister, Alan R.
N1 - Funding Information:
Supported by General Clinical Research Center grant (M01-RR00585; patient care, gastrointestinal, and immunochemistry cores) from the National Institutes of Health and by grants R01 DK67071 and K24 DK02638 to Dr Camilleri from the National Institutes of Health.
PY - 2006/12
Y1 - 2006/12
N2 - Background & Aims: Peptide YY (PYY) levels are reported to be decreased in obesity. The relation between gastric functions, satiation, and gut hormones in obesity is incompletely understood. The aim of this study was to compare gastric volumes, emptying, maximum tolerated volumes, postchallenge symptoms, and selected gut hormones in normal, overweight, or obese healthy volunteers. Methods: In 73 nonbulimic normal, overweight, or obese participants weighing less than 137 kg, we measured gastric emptying of solids and liquids by scintigraphy (gastric emptying half-time [GE t1/2]); gastric volumes by single-photon emission computed tomography; maximum tolerated volumes and symptoms by satiation test; and plasma leptin, ghrelin, insulin, glucagon-like peptide 1, and PYY levels. Groups were compared using 1-way analysis of covariance adjusted for sex. Univariate associations among measured responses were assessed using Spearman correlations. Multiple linear regression models, adjusting for weight and sex, assessed the independent ability of gastric functions and hormones to predict satiation volume. Results: Obese and overweight subjects had significantly lower postprandial gastric volumes, higher fasting and postprandial insulin and leptin levels, and lower fasting ghrelin and lower postprandial reduction in ghrelin levels. PYY levels were not different in obese or overweight subjects compared with controls. The GE t1/2 was correlated inversely with postprandial PYY; increased body weight was associated with faster GE t1/2 of solids (rs = 0.33, P = .005) and liquids (rs = 0.24, P = .04). Postprandial changes in gastric volume and PYY were independent predictors of satiation (both P = .01). Conclusions: Overweight or obesity are associated with lower postprandial gastric volumes and normal PYY levels. Gastric emptying influences postprandial PYY levels. Postprandial PYY and gastric volume independently predict satiation volume in nonbulimic people across a wide body mass index range.
AB - Background & Aims: Peptide YY (PYY) levels are reported to be decreased in obesity. The relation between gastric functions, satiation, and gut hormones in obesity is incompletely understood. The aim of this study was to compare gastric volumes, emptying, maximum tolerated volumes, postchallenge symptoms, and selected gut hormones in normal, overweight, or obese healthy volunteers. Methods: In 73 nonbulimic normal, overweight, or obese participants weighing less than 137 kg, we measured gastric emptying of solids and liquids by scintigraphy (gastric emptying half-time [GE t1/2]); gastric volumes by single-photon emission computed tomography; maximum tolerated volumes and symptoms by satiation test; and plasma leptin, ghrelin, insulin, glucagon-like peptide 1, and PYY levels. Groups were compared using 1-way analysis of covariance adjusted for sex. Univariate associations among measured responses were assessed using Spearman correlations. Multiple linear regression models, adjusting for weight and sex, assessed the independent ability of gastric functions and hormones to predict satiation volume. Results: Obese and overweight subjects had significantly lower postprandial gastric volumes, higher fasting and postprandial insulin and leptin levels, and lower fasting ghrelin and lower postprandial reduction in ghrelin levels. PYY levels were not different in obese or overweight subjects compared with controls. The GE t1/2 was correlated inversely with postprandial PYY; increased body weight was associated with faster GE t1/2 of solids (rs = 0.33, P = .005) and liquids (rs = 0.24, P = .04). Postprandial changes in gastric volume and PYY were independent predictors of satiation (both P = .01). Conclusions: Overweight or obesity are associated with lower postprandial gastric volumes and normal PYY levels. Gastric emptying influences postprandial PYY levels. Postprandial PYY and gastric volume independently predict satiation volume in nonbulimic people across a wide body mass index range.
UR - http://www.scopus.com/inward/record.url?scp=33845603200&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845603200&partnerID=8YFLogxK
U2 - 10.1053/j.gastro.2006.10.025
DO - 10.1053/j.gastro.2006.10.025
M3 - Article
C2 - 17087952
AN - SCOPUS:33845603200
SN - 0016-5085
VL - 131
SP - 1717
EP - 1724
JO - Gastroenterology
JF - Gastroenterology
IS - 6
ER -