TY - JOUR
T1 - Gastric emptying in postural tachycardia syndrome
T2 - A preliminary report
AU - Park, Ki Jong
AU - Singer, Wolfgang
AU - Sletten, David M.
AU - Low, Phillip A.
AU - Bharucha, Adil E.
N1 - Funding Information:
contribution was supported in part by the NIH (NS 44233). W.S. is supported by K23NS075141. The contents of this article are solely the responsibility of the author(s) and do not necessarily represent the official view of NCRR or NIH.
Funding Information:
Acknowledgments This study was supported by USPHS NIH Grant P01 DK068055 and UL1 RR024150-01* from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and the NIH Roadmap for Medical Research. P.L.’s
PY - 2013/8
Y1 - 2013/8
N2 - Purpose: Autonomic neuropathy is widely recognized to be associated with upper gastrointestinal symptoms and abnormal (i.e., rapid or slow) gastric emptying. While patients with postural orthostatic tachycardia syndrome (POTS) may also have gastrointestinal symptoms, our understanding of gastric-emptying disturbances in POTS is very limited. The objectives of this study were to evaluate the relationship between gastric-emptying disturbances and gastrointestinal symptoms in patients with POTS. Methods: We retrospectively reviewed the medical records of 22 well-characterized patients with POTS and upper gastrointestinal symptoms in whom autonomic (i.e., postganglionic sudomotor, cardiovagal, and adrenergic) functions and gastric emptying were evaluated using standardized techniques and scintigraphy, respectively. Medical records were reviewed retrospectively to assess clinical features, gastric emptying, and autonomic functions. Results: Over 70 % of patients had nausea and/or vomiting, which was the most common GI symptom; other common symptoms were abdominal pain (59 %), bloating (55 %), and postprandial fullness/early satiety (46 %). Over one-third of patients had abnormal [i.e., rapid (27 %) or delayed (9 %)] gastric emptying. Gastric-emptying disturbances were not significantly associated with GI symptoms, autonomic symptoms or autonomic dysfunction. Conclusions: Over one-third of patients with POTS and gastrointestinal symptoms have abnormal, more frequently rapid than delayed gastric emptying. These findings need to be confirmed in a larger cohort of patients.
AB - Purpose: Autonomic neuropathy is widely recognized to be associated with upper gastrointestinal symptoms and abnormal (i.e., rapid or slow) gastric emptying. While patients with postural orthostatic tachycardia syndrome (POTS) may also have gastrointestinal symptoms, our understanding of gastric-emptying disturbances in POTS is very limited. The objectives of this study were to evaluate the relationship between gastric-emptying disturbances and gastrointestinal symptoms in patients with POTS. Methods: We retrospectively reviewed the medical records of 22 well-characterized patients with POTS and upper gastrointestinal symptoms in whom autonomic (i.e., postganglionic sudomotor, cardiovagal, and adrenergic) functions and gastric emptying were evaluated using standardized techniques and scintigraphy, respectively. Medical records were reviewed retrospectively to assess clinical features, gastric emptying, and autonomic functions. Results: Over 70 % of patients had nausea and/or vomiting, which was the most common GI symptom; other common symptoms were abdominal pain (59 %), bloating (55 %), and postprandial fullness/early satiety (46 %). Over one-third of patients had abnormal [i.e., rapid (27 %) or delayed (9 %)] gastric emptying. Gastric-emptying disturbances were not significantly associated with GI symptoms, autonomic symptoms or autonomic dysfunction. Conclusions: Over one-third of patients with POTS and gastrointestinal symptoms have abnormal, more frequently rapid than delayed gastric emptying. These findings need to be confirmed in a larger cohort of patients.
KW - CASS
KW - COMPASS
KW - Dumping
KW - dysautonomia
KW - orthostatic intolerance
UR - http://www.scopus.com/inward/record.url?scp=84882267005&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882267005&partnerID=8YFLogxK
U2 - 10.1007/s10286-013-0193-y
DO - 10.1007/s10286-013-0193-y
M3 - Article
C2 - 23708963
AN - SCOPUS:84882267005
SN - 0959-9851
VL - 23
SP - 163
EP - 167
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
IS - 4
ER -