TY - JOUR
T1 - Gastric cancer in Alaska Native people
T2 - A cancer health disparity
AU - Martinson, Holly A.
AU - Shelby, Nancy J.
AU - Alberts, Steven R.
AU - Olnes, Matthew J.
N1 - Funding Information:
Supported by the Debbie’s Dream Foundation-AACR Gastric Cancer Research Fellowship under grant number 16-40-41-MART to HM and an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) under grant number P20GM103395 to HM, NS and MO. The content is solely the
Publisher Copyright:
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
PY - 2018/7/7
Y1 - 2018/7/7
N2 - AIM to evaluate recent trends in gastric cancer incidence, response to treatment, and overall survival among Alaska Native (AN) people. METHODS A retrospective analysis of the Alaska Native Medical Center patient database was performed. Patient history, clinical, pathological, response to treatment and patient outcomes were collected from one-hundred and thirty two AN gastric cancer patients. The Surveillance, Epidemiology and End Result database 18 was used to collect comparison United States non-Hispanic White (NHW) and AN gastric cancer patient data between 2006-2014. RESULTS AN gastric cancer patients have a higher incidence rate, a poorer overall survival, and are diagnosed at a significantly younger age compared to NHW patients. AN patients differ from NHW patients in greater prevalence of non-cardia, diffuse subtype, and signet ring cell carcinomas. AN females were more likely to be diagnosed with later stage cancer, stage IV, compared to AN males. Diminished overall survival was observed among AN patients with increasing stage, O+ blood type, < 15 lymph nodes examined at resection, and no treatment. This study is the first report detailing the clinicopathologic features of gastric cancer in AN people with outcome data. CONCLUSION Our findings confirm the importance of early detection, treatment, and surgical resection for optimizing AN patient outcomes. Further research on early detection markers are warranted.
AB - AIM to evaluate recent trends in gastric cancer incidence, response to treatment, and overall survival among Alaska Native (AN) people. METHODS A retrospective analysis of the Alaska Native Medical Center patient database was performed. Patient history, clinical, pathological, response to treatment and patient outcomes were collected from one-hundred and thirty two AN gastric cancer patients. The Surveillance, Epidemiology and End Result database 18 was used to collect comparison United States non-Hispanic White (NHW) and AN gastric cancer patient data between 2006-2014. RESULTS AN gastric cancer patients have a higher incidence rate, a poorer overall survival, and are diagnosed at a significantly younger age compared to NHW patients. AN patients differ from NHW patients in greater prevalence of non-cardia, diffuse subtype, and signet ring cell carcinomas. AN females were more likely to be diagnosed with later stage cancer, stage IV, compared to AN males. Diminished overall survival was observed among AN patients with increasing stage, O+ blood type, < 15 lymph nodes examined at resection, and no treatment. This study is the first report detailing the clinicopathologic features of gastric cancer in AN people with outcome data. CONCLUSION Our findings confirm the importance of early detection, treatment, and surgical resection for optimizing AN patient outcomes. Further research on early detection markers are warranted.
KW - Alaska Native
KW - Gastric cancer
KW - Gender
KW - Health disparities
KW - Helicobacter pylori
UR - http://www.scopus.com/inward/record.url?scp=85049688967&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049688967&partnerID=8YFLogxK
U2 - 10.3748/wjg.v24.i25.2722
DO - 10.3748/wjg.v24.i25.2722
M3 - Article
C2 - 29991877
AN - SCOPUS:85049688967
SN - 1007-9327
VL - 24
SP - 2722
EP - 2732
JO - World journal of gastroenterology
JF - World journal of gastroenterology
IS - 25
ER -