Gamma Knife radiosurgery for neurofibromatosis type 2-associated meningiomas: a 22-year patient series

Brandon Birckhead, Terence T. Sio, Bruce E. Pollock, Michael J. Link, Nadia N. Laack

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Neurofibromatosis type 2 (NF2) is a debilitating genetic condition with potential development of multiple meningiomas. We report our experience treating a series of NF2-associated intracranial meningiomas with Gamma Knife radiosurgery (GKRS). Between 1992 and 2013, 15 consecutive patients (age 20–54 years) with 62 intracranial meningiomas were treated with single-fraction GKRS. Fifty-five percent of tumors involved the convexity or parasagittal/falx. The median prescription dose was 16 Gy (range 13–20 Gy). The median tumor diameter was 2.1 cm (range 0.7–4.5 cm). The median radiographic and clinical follow-up periods were 103 and 111 months, respectively. The 5-year and 10-year local controls were both 96 %. The disease specific survival was 93 % at 5 years and 68 % at 10 years. Fifty-three percent of patients had multiple meningiomas and received multiple GKRS treatments (range 1–7) for new or enlarging intracranial meningiomas. 11 (73 %) patients were alive at last follow-up, with 60 (97 %) tumors controlled (smaller or unchanged in size). There were 2 in-field failures, one at 1 year and the other at 3.5 years. There were no marginal failures. Major Complications after GKRS included: 1 case of radiation necrosis, 1 case of post treatment edema, and 1 case of a presumed radiation induced cavernous malformation 5 years after GKRS. GK is an effective treatment for enlarging NF2–associated meningiomas. No cases of malignant transformation or secondary malignancies were seen during the follow-up period.

Original languageEnglish (US)
Pages (from-to)553-560
Number of pages8
JournalJournal of neuro-oncology
Issue number3
StatePublished - Dec 1 2016


  • Gamma Knife
  • Meningioma
  • Neurofibromatosis
  • Radiotherapy
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research


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