Fungal Infection in Lung Transplantation

Cassie C. Kennedy, Kelly M. Pennington, Elena Beam, Raymund R. Razonable

Research output: Contribution to journalArticlepeer-review


Invasive fungal infections threaten lung transplant outcomes with high associated morbidity and mortality. Pharmacologic prophylaxis may be key to prevent posttransplant invasive fungal infections, but cost, adverse effects, and absorption issues are barriers to effective prophylaxis. Trends in fungal infection diagnostic strategies utilize molecular diagnostic methodologies to complement traditional histopathology and culture techniques. While lung transplant recipients are susceptible to a variety of fungal pathogens, Candida spp. and Aspergillus spp. infections remain the most common. With emerging resistant organisms and multiple novel antifungal agents in the research pipeline, it is likely that treatment strategies will continue to evolve.

Original languageEnglish (US)
Pages (from-to)471-482
Number of pages12
JournalSeminars in Respiratory and Critical Care Medicine
Issue number3
StatePublished - Jun 1 2021


  • antifungal prophylaxis
  • fungal infection
  • immunocompromised
  • lung transplant

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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