TY - JOUR
T1 - Fungal Infection in Lung Transplantation
AU - Kennedy, Cassie C.
AU - Pennington, Kelly M.
AU - Beam, Elena
AU - Razonable, Raymund R.
N1 - Funding Information:
C.C.K. is funded in part by National Institute of Health (NIH) HL 128859. The manuscript’s contents are solely the responsibility of the authors and do not necessarily represent the official view of the NIH.
Publisher Copyright:
© 2020 American Institute of Physics Inc.. All rights reserved.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Invasive fungal infections threaten lung transplant outcomes with high associated morbidity and mortality. Pharmacologic prophylaxis may be key to prevent posttransplant invasive fungal infections, but cost, adverse effects, and absorption issues are barriers to effective prophylaxis. Trends in fungal infection diagnostic strategies utilize molecular diagnostic methodologies to complement traditional histopathology and culture techniques. While lung transplant recipients are susceptible to a variety of fungal pathogens, Candida spp. and Aspergillus spp. infections remain the most common. With emerging resistant organisms and multiple novel antifungal agents in the research pipeline, it is likely that treatment strategies will continue to evolve.
AB - Invasive fungal infections threaten lung transplant outcomes with high associated morbidity and mortality. Pharmacologic prophylaxis may be key to prevent posttransplant invasive fungal infections, but cost, adverse effects, and absorption issues are barriers to effective prophylaxis. Trends in fungal infection diagnostic strategies utilize molecular diagnostic methodologies to complement traditional histopathology and culture techniques. While lung transplant recipients are susceptible to a variety of fungal pathogens, Candida spp. and Aspergillus spp. infections remain the most common. With emerging resistant organisms and multiple novel antifungal agents in the research pipeline, it is likely that treatment strategies will continue to evolve.
KW - antifungal prophylaxis
KW - fungal infection
KW - immunocompromised
KW - lung transplant
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U2 - 10.1055/s-0041-1729173
DO - 10.1055/s-0041-1729173
M3 - Article
C2 - 34030208
AN - SCOPUS:85106734223
SN - 1069-3424
VL - 42
SP - 471
EP - 482
JO - Seminars in Respiratory and Critical Care Medicine
JF - Seminars in Respiratory and Critical Care Medicine
IS - 3
ER -