Functional impact of white matter hyperintensities in cognitively normal elderly subjects

Melissa E. Murray, Matthew L. Senjem, Ronald C. Petersen, John H. Hollman, Greg M. Preboske, Stephen D. Weigand, David S. Knopman, Tanis J. Ferman, Dennis W. Dickson, Clifford R. Jack

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


Objective: To investigate the impact white matter hyperintensities (WMH) detected on magnetic resonance imaging have on motor dysfunction and cognitive impairment in elderly subjects without dementia. Design: Cross-sectional study. Setting: Population-based study on the incidence and prevalence of cognitive impairment in Olmsted County, Minnesota. Participants: A total of 148 elderly subjects (65 men) without dementia ranging in age from 73 to 91 years. Main Outcome Measures: We measured the percentage of the total white matter volume classified as WMH in a priori-defined brain regions (ie, frontal, temporal, parietal, occipital, periventricular, or subcortical). Motor impairment was evaluated qualitatively using the Unified Parkinson's Disease Rating Scale summary measures of motor skills and quantitatively using a digitized portable walkway system. Four cognitive domains were evaluated using z scores of memory, language, executive function, and visuospatial reasoning. Results: A higher WMH proportion in all regions except the occipital lobewasassociated with lower executive function z score (P value <.01). A higher WMH proportion in all regions, butmoststrongly for the parietal lobe, correlated with higher Unified Parkinson's Disease Rating Scale gait, posture,andpostural stabilitysum(P value <.01).Ahigher WMH proportion, whether periventricular, subcortical, or lobar, correlated with reduced velocity (P value <.001). Conclusions: We conclude that executive function is the primary cognitive domain affected by WMH burden. The data suggest that WMH in the parietal lobe are chiefly responsible for reduced balance and postural support compared with the other 3 lobes and may alter integration of sensory information via parietal lobe dysfunction in the aging brain. Parietal white matter changes were not the pre-dominant correlate with motor speed, lending evidence to a global involvement of neural networks in gait velocity.

Original languageEnglish (US)
Pages (from-to)1379-1385
Number of pages7
JournalArchives of neurology
Issue number11
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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