Functional dyspepsia: Symptoms and underlying mechanism

Michael Camilleri, David G. Thompson, Juan R. Malagelada

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


We define the concept of functional dyspepsia and analyze the putative mechanisms involved in its pathogenesis. We consider the evidence for gastroduodenitis, including the relationship of spiral organisms and viruses in this entity, and for functional dyspepsia as a manifestation of gastric secretory dysfunction and upper gut dysmotility. Functional dyspepsia is probably a heterogeneous condition in which multiple etiopathogenetic mechanisms are involved. Nevertheless, patients with functional dyspepsia constitute a sizable fraction of gastroenterological practice and therefore this disorder deserves intense research.

Original languageEnglish (US)
Pages (from-to)424-429
Number of pages6
JournalJournal of clinical gastroenterology
Issue number4
StatePublished - Aug 1986


  • Acid-peptic disease
  • Campylobacter-like organisms
  • Catecholamines
  • Functional dyspepsia
  • Gastric motility
  • Gastroduodenitis
  • Gut hormones
  • Nonulcer dyspepsia
  • Stress

ASJC Scopus subject areas

  • Gastroenterology


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