Functional and cognitive outcome in prolonged refractory status epilepticus

Alex D. Cooper, Jeffrey W. Britton, Alejandro A. Rabinstein

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Objective: To determine the functional and cognitive outcomes of patients with prolonged refractory status epilepticus (PRSE) lasting 7 or more days despite the use of anesthetic agents for seizure suppression. Design: Retrospective analysis. Setting: St Mary's Hospital, Mayo Clinic, Rochester, Minnesota. Participants: Fourteen patients with PRSE. Intervention: Hospital follow-up interview. Main Outcome Measures: Survival rate of PRSE and functional and cognitive outcome of surviving patients based on the modified Rankin Scale (mRS) and Telephone Interview for Cognitive Status (TICS). Results: Forty-three percent of patients (6 of 14) died during hospitalization for PRSE, and 57% (8 of 14) had died by the last follow-up. Of the 6 surviving patients, 4 showed improvement and 2 showed no change in mRS score (median mRS change,-1; range, 0 to -3). Owing to preexisting cognitive deficits, 1 patient could not complete the TICS. The 5 remaining patients scored a median of 34 on the TICS (range, 30-37; reference TICS score, ≥31; maximum TICS score,41). Age, sex, PRSE duration, and etiology were not associated with chance of survival. Conclusions: Despite the high mortality rate, survival with meaningful functional and cognitive recovery is possible after PRSE. Prolonged duration of status epilepticus alone should not be considered a reason to discontinue treatment.

Original languageEnglish (US)
Pages (from-to)1505-1509
Number of pages5
JournalArchives of neurology
Issue number12
StatePublished - Dec 2009

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


Dive into the research topics of 'Functional and cognitive outcome in prolonged refractory status epilepticus'. Together they form a unique fingerprint.

Cite this