Abstract
Wessel et al. use iPOND purifications and loss-of-function analyses to identify and characterize a replication fork and nascent chromatin proteome of 593 proteins. They demonstrate the resource's utility by showing that the BET proteins BRD2, BRD3, and BRD4 inhibit ATAD5-dependent PCNA unloading from chromatin.
Original language | English (US) |
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Pages (from-to) | 3497-3509.e4 |
Journal | Cell reports |
Volume | 28 |
Issue number | 13 |
DOIs | |
State | Published - Sep 24 2019 |
Keywords
- ATAD5
- BET domain
- DNA replication
- PCNA
- chromatin
- iPOND
- proteomics
- replisome
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology