@article{4b5fd433441c468992713d97ab8eb7e9,
title = "Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators",
abstract = "Wessel et al. use iPOND purifications and loss-of-function analyses to identify and characterize a replication fork and nascent chromatin proteome of 593 proteins. They demonstrate the resource's utility by showing that the BET proteins BRD2, BRD3, and BRD4 inhibit ATAD5-dependent PCNA unloading from chromatin.",
keywords = "ATAD5, BET domain, DNA replication, PCNA, chromatin, iPOND, proteomics, replisome",
author = "Wessel, {Sarah R.} and Mohni, {Kareem N.} and Luzwick, {Jessica W.} and Huzefa Dungrawala and David Cortez",
note = "Funding Information: This research was supported by grants to D.C. from the NIH ( R01GM116616 and R01CA239161 ) and the Breast Cancer Research Foundation . K.N.M. was supported by the Susan G. Komen fellowships PDF14302198 and 5T32CA009582 . S.R.W. was supported by NIH F32 GM126646 and 5T32CA009582 . Additional support came from the Vanderbilt-Ingram Cancer Center . We thank Kyungjae Myung for providing ATAD5 reagents. Funding Information: This research was supported by grants to D.C. from the NIH (R01GM116616 and R01CA239161) and the Breast Cancer Research Foundation. K.N.M. was supported by the Susan G. Komen fellowships PDF14302198 and 5T32CA009582. S.R.W. was supported by NIH F32 GM126646 and 5T32CA009582. Additional support came from the Vanderbilt-Ingram Cancer Center. We thank Kyungjae Myung for providing ATAD5 reagents. S.R.W. K.N.M. J.W.L. and H.D. performed experiments. S.R.W. K.N.M. and J.W.L. analyzed the data. S.R.W. K.N.M. and D.C. conceived of the project and wrote the manuscript. D.C. supervised the project. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = sep,
day = "24",
doi = "10.1016/j.celrep.2019.08.051",
language = "English (US)",
volume = "28",
pages = "3497--3509.e4",
journal = "Cell reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "13",
}