TY - JOUR
T1 - Full field-of-view, high-resolution, photon-counting detector CT
T2 - Technical assessment and initial patient experience
AU - Rajendran, Kishore
AU - Petersilka, Martin
AU - Henning, André
AU - Shanblatt, Elisabeth
AU - Marsh, Jeffrey
AU - Thorne, Jamison
AU - Schmidt, Bernhard
AU - Flohr, Thomas
AU - Fletcher, Joel
AU - McCollough, Cynthia
AU - Leng, Shuai
N1 - Publisher Copyright:
© 2021 Institute of Physics Publishing. All rights reserved.
PY - 2021/10/21
Y1 - 2021/10/21
N2 - Wereport a comprehensive evaluation of a full field-of-view (FOV) photon-counting detector (PCD) computed tomography (CT) system using phantoms, and qualitatively assess image quality in patient examples.Awhole-body PCD-CTsystemwith 50 cmFOV, 5.76 cmz-detector coverage and two acquisitionmodes (standard: 144 × 0.4mmcollimation and ultra-high resolution (UHR): 120 ×0.2mm collimation) was used in this study. Phantomswere scanned to assess image uniformity, CTnumber accuracy, noise power spectrum, spatial resolution, material decomposition and virtualmonoenergetic imaging (VMI) performance. Four patientswere scanned on thePCD-CTsystemwith matched or lower radiation dose than their prior clinicalCTscans performed using energy-integrating detector (EID) CT, and the potential clinical impact of PCD-CTwas qualitatively evaluated. Phantom results showedwater CTnumberswithin±5HU, and image uniformitymeasured between peripheral and central regions-ofinterests to bewithin±5HU. For theUHRmode using a dedicated sharp kernel, the cut-off spatial frequencywas 40 line-pairscm-1,which corresponds to a 125μmlimiting in-plane spatial resolution. The full-width-at-half-maximumfor the section sensitivity profile was 0.33mmfor the smallest slice thickness (0.2mm) using theUHRmode.Material decomposition in a multi-energyCTphantom showed accurate material classification, with a root-mean-squared-error of 0.3mg cc-1 for iodine concentrations (2-15mgcc-1) and 14.2mg cc-1 for hydroxyapatite concentrations (200 and 400mgcc-1).The average percent error forCTnumbers corresponding to the iodine concentrations inVMI(40-70 keV) was 2.75%. Patient PCD-CTimages demonstrated better delineation of anatomy for chest and temporal bone exams performedwith theUHRmode,whichallowed theuseof very sharp kernels not possible with EID-CT. VMIand virtual non-contrast images generated froma patient headCTangiography exam using the standard acquisitionmode demonstrated themulti-energy capability of thePCD-CTsystem.
AB - Wereport a comprehensive evaluation of a full field-of-view (FOV) photon-counting detector (PCD) computed tomography (CT) system using phantoms, and qualitatively assess image quality in patient examples.Awhole-body PCD-CTsystemwith 50 cmFOV, 5.76 cmz-detector coverage and two acquisitionmodes (standard: 144 × 0.4mmcollimation and ultra-high resolution (UHR): 120 ×0.2mm collimation) was used in this study. Phantomswere scanned to assess image uniformity, CTnumber accuracy, noise power spectrum, spatial resolution, material decomposition and virtualmonoenergetic imaging (VMI) performance. Four patientswere scanned on thePCD-CTsystemwith matched or lower radiation dose than their prior clinicalCTscans performed using energy-integrating detector (EID) CT, and the potential clinical impact of PCD-CTwas qualitatively evaluated. Phantom results showedwater CTnumberswithin±5HU, and image uniformitymeasured between peripheral and central regions-ofinterests to bewithin±5HU. For theUHRmode using a dedicated sharp kernel, the cut-off spatial frequencywas 40 line-pairscm-1,which corresponds to a 125μmlimiting in-plane spatial resolution. The full-width-at-half-maximumfor the section sensitivity profile was 0.33mmfor the smallest slice thickness (0.2mm) using theUHRmode.Material decomposition in a multi-energyCTphantom showed accurate material classification, with a root-mean-squared-error of 0.3mg cc-1 for iodine concentrations (2-15mgcc-1) and 14.2mg cc-1 for hydroxyapatite concentrations (200 and 400mgcc-1).The average percent error forCTnumbers corresponding to the iodine concentrations inVMI(40-70 keV) was 2.75%. Patient PCD-CTimages demonstrated better delineation of anatomy for chest and temporal bone exams performedwith theUHRmode,whichallowed theuseof very sharp kernels not possible with EID-CT. VMIand virtual non-contrast images generated froma patient headCTangiography exam using the standard acquisitionmode demonstrated themulti-energy capability of thePCD-CTsystem.
KW - Image analysis
KW - Photon-counting detector
KW - Spatial resolution
KW - x-ray computed tomography
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U2 - 10.1088/1361-6560/ac155e
DO - 10.1088/1361-6560/ac155e
M3 - Article
C2 - 34271558
AN - SCOPUS:85119074833
SN - 0031-9155
VL - 66
JO - Physics in medicine and biology
JF - Physics in medicine and biology
IS - 20
M1 - 205019
ER -