Frontotemporal dementia and parkinsonism

D. Crosiers, C. Wider, Z. K. Wszolek

Research output: Chapter in Book/Report/Conference proceedingChapter


Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia. Major symptoms include behavioral disturbances and language impairment. Diagnosis relies upon history, clinical examination, neuropsychological assessment and brain imaging, showing evidence of frontotemporal involvement. Mutations in several genes have been associated with FTD, explaining the familial aggregation and heritability of FTD. Pathologically, there is frontotemporal atrophy on macroscopic level, while on microscopic level neuronal loss, gliosis and several types of neuronal inclusions are observed. FTD carries a poor prognosis, with a median 8-year survival from symptom onset.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Number of pages8
ISBN (Electronic)9780128093245
StatePublished - Jan 1 2016


  • C9orf72
  • FTLD
  • Frontotemporal dementia (FTD)
  • GRN
  • MAPT
  • Parkinsonism
  • Primary progressive aphasia (PPA)
  • Progressive nonfluent aphasia (PNFA)
  • Semantic dementia (SD)
  • TDP-43

ASJC Scopus subject areas

  • General Medicine


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