TY - JOUR
T1 - Frequent occurrence of cytogenetic abnormalities in sporadic nonmedullary thyroid carcinoma
AU - Jenkins, Robert B.
AU - Hay, Ian D.
AU - Herath, John F.
AU - Schultz, Cloann G.
AU - Spurbeck, Jack L.
AU - Grant, Clive S.
AU - Goellner, John R.
AU - Dewald, Gordon W.
PY - 1990/9/15
Y1 - 1990/9/15
N2 - Cytogenetic studies may provide important clues to the molecular pathogenesis of thyroid neoplasia. Thus, the authors attempted cytogenetic studies on 12 thyroid carcinomas: seven papillary, three follicular, and two anaplastic. Successful cytogenetic results were obtained on all 12 tumors; nine (75%) had one or more chromosomally abnormal clones. Four of the papillary carcinomas had a simple clonal karyotype, and three had no apparent chromosome abnormality. All four abnormal papillary tumors contained an anomaly of a chromosome 10q arm. In one instance, an inv(10)(q11.2q21.2) was observed in a Grade 2 papillary carcinoma as the sole acquired abnormality. In another case, an inversion or insertion involving 10q21.2 was found in a Grade 1 papillary tumor. The karyotype of a third tumor, a Grade 1 papillary carcinoma, was 46,XX,der(5)t(5;10)(p15.3;q11),der(9)t(9;?)(q11;?). A fourth abnormal papillary carcinoma, a Grade 1 tumor, had a t(6;10)(q21;q26.1) as the sole abnormality. Each of the five follicular or anaplastic carcinomas had a complex clonal karyotype. The three follicular carcinomas contained an abnormality of 3p25–p21, along with several other chromosome abnormalities.
AB - Cytogenetic studies may provide important clues to the molecular pathogenesis of thyroid neoplasia. Thus, the authors attempted cytogenetic studies on 12 thyroid carcinomas: seven papillary, three follicular, and two anaplastic. Successful cytogenetic results were obtained on all 12 tumors; nine (75%) had one or more chromosomally abnormal clones. Four of the papillary carcinomas had a simple clonal karyotype, and three had no apparent chromosome abnormality. All four abnormal papillary tumors contained an anomaly of a chromosome 10q arm. In one instance, an inv(10)(q11.2q21.2) was observed in a Grade 2 papillary carcinoma as the sole acquired abnormality. In another case, an inversion or insertion involving 10q21.2 was found in a Grade 1 papillary tumor. The karyotype of a third tumor, a Grade 1 papillary carcinoma, was 46,XX,der(5)t(5;10)(p15.3;q11),der(9)t(9;?)(q11;?). A fourth abnormal papillary carcinoma, a Grade 1 tumor, had a t(6;10)(q21;q26.1) as the sole abnormality. Each of the five follicular or anaplastic carcinomas had a complex clonal karyotype. The three follicular carcinomas contained an abnormality of 3p25–p21, along with several other chromosome abnormalities.
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U2 - 10.1002/1097-0142(19900915)66:6<1213::AID-CNCR2820660622>3.0.CO;2-9
DO - 10.1002/1097-0142(19900915)66:6<1213::AID-CNCR2820660622>3.0.CO;2-9
M3 - Article
C2 - 2400971
AN - SCOPUS:0025035484
SN - 0008-543X
VL - 66
SP - 1213
EP - 1220
JO - Cancer
JF - Cancer
IS - 6
ER -