FREQUENCY OF SEVERE NEUTROPENIA ASSOCIATED WITH AMODIAQUINE PROPHYLAXIS AGAINST MALARIA

C. S.R. Hatton; C. Bunch; T. E.A. Peto; G. Pasvol; S. J. Russell; C. R.J. Singer; G. Edwards; P. Winstanley

doi:10.1016/S0140-6736(86)92371-8

FREQUENCY OF SEVERE NEUTROPENIA ASSOCIATED WITH AMODIAQUINE PROPHYLAXIS AGAINST MALARIA

C. S.R. Hatton, C. Bunch, T. E.A. Peto, G. Pasvol, S. J. Russell, C. R.J. Singer, G. Edwards, P. Winstanley

Molecular Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken co-trimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000.

Original language	English (US)
Pages (from-to)	411-414
Number of pages	4
Journal	The Lancet
Volume	327
Issue number	8478
DOIs	https://doi.org/10.1016/S0140-6736(86)92371-8
State	Published - Feb 22 1986

ASJC Scopus subject areas

Medicine(all)

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title = "FREQUENCY OF SEVERE NEUTROPENIA ASSOCIATED WITH AMODIAQUINE PROPHYLAXIS AGAINST MALARIA",

abstract = "6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken co-trimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000.",

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AU - Hatton, C. S.R.

AU - Bunch, C.

AU - Peto, T. E.A.

AU - Pasvol, G.

AU - Russell, S. J.

AU - Singer, C. R.J.

AU - Edwards, G.

AU - Winstanley, P.

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AB - 6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken co-trimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000.

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FREQUENCY OF SEVERE NEUTROPENIA ASSOCIATED WITH AMODIAQUINE PROPHYLAXIS AGAINST MALARIA

Abstract

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