Frequency of New or Enlarging Lesions on MRI Outside of Clinical Attacks in Patients with MOG-Antibody-Associated Disease

Stephanie B. Syc-Mazurek, John J. Chen, Pearse Morris, Elia Sechi, Jaywant Mandrekar, Jan Mendelt Tillema, A. Sebastian Lopez-Chiriboga, Claudia Francesca Lucchinetti, Nicholas Zalewski, Laura Cacciaguerra, Marina Buciuc, Karl N. Krecke, Steven Anthony Messina, M. Tariq Bhatti, Sean J. Pittock, Eoin P. Flanagan

Research output: Contribution to journalArticlepeer-review


Background and ObjectiveTo determine the frequency of new or enlarging T2-hyperintense or enhancing lesions outside of clinical attacks in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) vs multiple sclerosis (MS) and aquaporin-4 antibody positive neuromyelitis optica spectrum disorder (AQP4+NMOSD).MethodsWe retrospectively included Mayo Clinic patients with MOGAD with: (1) MOG-Immunoglobulin-G positivity by live cell-based assay, (2) fulfilling proposed MOGAD diagnostic criteria, and (3) baseline and follow-up paired MRIs without interval attacks. A neurologist and neuroradiologist reviewed MRIs (T2-fluid attenuated inversion recovery brain, T2 spine, and T1-postgadolinium brain and spine) to identify new or enlarging lesions. A MOGAD subset was then compared to patients with MS and AQP4+NMOSD, based on broadly similar interscan intervals.ResultsWe included 105 patients with MOGAD (median age, 31 years [range, 2-80]; 60% female) with 373 paired MRIs. In total, 10/105 (9.5%) patients and 13/373 (3%) scans had one or more new T2 lesions (brain, 12/213 [6%]; spine, 1/160 [0.6%]); and 8/367 (2%) had enhancing lesions. New brain lesions were less in MOGAD (1/25 [4%]) than MS (14/26 [54%], p < 0.0001) but did not differ from AQP4+NMOSD (1/13 [8%], p = 1.0) in subgroup analysis. New spinal lesions were rare across groups (0%-4%).DiscussionNew or enlarging MRI lesions rarely develop outside of clinical attacks in MOGAD differing from MS. Surveillance MRIs in MOGAD have limited utility with implications for clinical practice and trial design.

Original languageEnglish (US)
Pages (from-to)795-799
Number of pages5
Issue number18
StatePublished - Nov 1 2022

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Frequency of New or Enlarging Lesions on MRI Outside of Clinical Attacks in Patients with MOG-Antibody-Associated Disease'. Together they form a unique fingerprint.

Cite this