Fluorescence in situ hybridization in diagnostic cytology

Kevin C. Halling, Benjamin R. Kipp

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


Fluorescence in situ hybridization (FISH) is a technique that uses fluorescently labeled DNA probes to detect chromosomal alterations in cells. FISH can detect various types of cytogenetic alterations including aneusomy (ie, abnormalities of chromosome copy number), duplication, amplification, deletion, and translocation. Because tumor cells generally contain chromosomal alterations, FISH is able to detect cells that have chromosomal abnormalities consistent with neoplasia in exfoliative and aspiration cytology specimens. This review will discuss the utility of FISH for the detection of bladder, lung, pancreatobiliary, and esophageal carcinoma in cytologic specimens.

Original languageEnglish (US)
Pages (from-to)1137-1144
Number of pages8
JournalHuman Pathology
Issue number8
StatePublished - Aug 2007


  • Barrett's esophagus
  • Biliary tract
  • Bladder cancer
  • Cytology
  • FISH
  • Fluorescence in situ hybridization
  • Lung cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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