@article{14e48c166b2c41ad80c42e74ecc778f2,
title = "Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium",
abstract = "The Lewy Body Dementia Association (LBDA) held a virtual event, the LBDA Biofluid/Tissue Biomarker Symposium, on January 25, 2021, to present advances in biomarkers for Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLBs) and Parkinson's disease dementia (PDD). The meeting featured eight internationally known scientists from Europe and the United States and attracted over 200 scientists and physicians from academic centers, the National Institutes of Health, and the pharmaceutical industry. Methods for confirming and quantifying the presence of Lewy body and Alzheimer's pathology and novel biomarkers were discussed.",
keywords = "LBDA biomarker symposium, Lewy body dementia, alpha-synuclein, amyloid, cerebrospinal fluid, seeded aggregation assays, skin biopsy, tau",
author = "Scott, {Gregory D.} and Arnold, {Moriah R.} and Beach, {Thomas G.} and Gibbons, {Christopher H.} and Kanthasamy, {Anumantha G.} and Lebovitz, {Russell M.} and Lemstra, {Afina W.} and Shaw, {Leslie M.} and Teunissen, {Charlotte E.} and Henrik Zetterberg and Taylor, {Angela S.} and Graham, {Todd C.} and Boeve, {Bradley F.} and Gomperts, {Stephen N.} and Graff-Radford, {Neill R.} and Charbel Moussa and Poston, {Kathleen L.} and Rosenthal, {Liana S.} and Sabbagh, {Marwan N.} and Walsh, {Ryan R.} and Weber, {Miriam T.} and Armstrong, {Melissa J.} and Bang, {Jee A.} and Bozoki, {Andrea C.} and Kimiko Domoto-Reilly and Duda, {John E.} and Fleisher, {Jori E.} and Galasko, {Douglas R.} and Galvin, {James E.} and Goldman, {Jennifer G.} and Holden, {Samantha K.} and Honig, {Lawrence S.} and Huddleston, {Daniel E.} and Leverenz, {James B.} and Irene Litvan and Manning, {Carol A.} and Marder, {Karen S.} and Pantelyat, {Alexander Y.} and Pelak, {Victoria S.} and Scharre, {Douglas W.} and Sha, {Sharon J.} and Shill, {Holly A.} and Zoltan Mari and Quinn, {Joseph F.} and Irwin, {David J.}",
note = "Funding Information: Unified Parkinson{\textquoteright}s Disease Rating Scale (UPDRS), Orientation and Mobility Severity Rating Scale (OMSR), and DLB Cognitive Scale (unpublished). Biopsy acquisition was performed, using the SYN-ONE test, as part of a multicenter center study supported by the NIH Office of Rare Diseases (Autonomic Disorders Consortium). An additional multisite blinded study funded by NIH is currently underway to evaluate how this approach fares in the environment of multiple academic and private practice sites with a core reference laboratory-developed test. The skin biopsies prepared in this manner can also be quantified, and the first quantitative studies show significant autonomic and sensory nerve fiber density differences between groups, individuals with DLB having the most severe autonomic and sensory neuropathies, followed by idiopathic PD, and finally multiple system atrophy (MSA), without evidence of peripheral nerve degeneration. Dr. Gibbon{\textquoteright}s group also recently reported that cutaneous phospho-alpha-synuclein is moderately correlated (r = 0.6) with both sympathetic and total autonomic impairment in individuals with isolated REM sleep behavior disorder (iRBD) and is more common in iRBD with hyposmia (26). Funding Information: This study is supported by the Lewy Body Dementia Association. Publisher Copyright: Copyright {\textcopyright} 2022 Scott, Arnold, Beach, Gibbons, Kanthasamy, Lebovitz, Lemstra, Shaw, Teunissen, Zetterberg, Taylor, Graham, Boeve, Gomperts, Graff-Radford, Moussa, Poston, Rosenthal, Sabbagh, Walsh, Weber, Armstrong, Bang, Bozoki, Domoto-Reilly, Duda, Fleisher, Galasko, Galvin, Goldman, Holden, Honig, Huddleston, Leverenz, Litvan, Manning, Marder, Pantelyat, Pelak, Scharre, Sha, Shill, Mari, Quinn and Irwin.",
year = "2022",
month = jan,
day = "31",
doi = "10.3389/fneur.2021.805135",
language = "English (US)",
volume = "12",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",
}