TY - JOUR
T1 - Floxuridine‐induced sclerosing cholangitis
T2 - An ischemic cholangiopathy?
AU - Ludwig, Jurgen
AU - Kim, Chung H.
AU - Wiesner, Russell H.
AU - Krom, Ruud A.F.
PY - 1989/2
Y1 - 1989/2
N2 - A 43‐year‐old man underwent abdominoperineal resection of a rectal adenocarcinoma, and left hepatic lobectomy for a single metastasis. He then received hepatic artery infusions of floxuridine. The tumor did not recur, but sclerosing cholangitis and liver failure developed which necessitated orthotopic liver transplantation. In the hilus of the native liver, obstructive arteriopathy and portal venopathy were found. These lesions probably had been caused by drug‐induced intravascular thrombosis. Thus, the sclerosing cholangitis that develops in many patients after floxuridine infusion may be ischemic rather than toxic. The patient described here is well, 14 months after orthotopic liver transplantation. Therefore, in some cases of floxuridine‐induced cholangitis, liver transplantation appears to be indicated despite a history of metastasizing carcinoma.
AB - A 43‐year‐old man underwent abdominoperineal resection of a rectal adenocarcinoma, and left hepatic lobectomy for a single metastasis. He then received hepatic artery infusions of floxuridine. The tumor did not recur, but sclerosing cholangitis and liver failure developed which necessitated orthotopic liver transplantation. In the hilus of the native liver, obstructive arteriopathy and portal venopathy were found. These lesions probably had been caused by drug‐induced intravascular thrombosis. Thus, the sclerosing cholangitis that develops in many patients after floxuridine infusion may be ischemic rather than toxic. The patient described here is well, 14 months after orthotopic liver transplantation. Therefore, in some cases of floxuridine‐induced cholangitis, liver transplantation appears to be indicated despite a history of metastasizing carcinoma.
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U2 - 10.1002/hep.1840090209
DO - 10.1002/hep.1840090209
M3 - Article
C2 - 2521475
AN - SCOPUS:0024542414
SN - 0270-9139
VL - 9
SP - 215
EP - 218
JO - Hepatology
JF - Hepatology
IS - 2
ER -