Flow Cytometry Applications in the Diagnosis of T/NK-Cell Lymphoproliferative Disorders

Dragan Jevremovic, Horatiu Olteanu

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


This article provides an overview of the role of flow cytometry in the diagnosis, prognosis, and follow-up of T and NK-cell lymphoproliferative disorders. For each category, we will briefly discuss the immunophenotypic features of normal T and NK cells, and address technical issues in flow cytometry, the approach to diagnosis in various contexts, pitfalls in interpretation, and its use in follow-up and post-therapy management. In addition to reviewing the diagnostic, prognostic, and therapeutic utility of flow cytometric immunophenotyping in several of specific T and NK cell entities, we will also cover some of the new immunophenotypic markers. Furthermore, we will touch upon incorporation of flow cytometry in the final diagnosis, including correlation with other ancillary tests.

Original languageEnglish (US)
Pages (from-to)99-115
Number of pages17
JournalCytometry Part B - Clinical Cytometry
Issue number2
StatePublished - Mar 2019


  • NK-cell lymphoproliferative disorders
  • T-cell lymphoproliferative disorder
  • flow cytometry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


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