TY - JOUR
T1 - Flow Cytometric Immune Profiling in Infliximab-Associated Tuberculosis
AU - Pennington, Kelly
AU - Sasieta, Humberto C.
AU - Ramos, Guiherme P.
AU - Erskine, Courtney L.
AU - Van Keulen, Virginia P.
AU - Peikert, Tobias
AU - Escalante, Patricio
N1 - Publisher Copyright:
© 2017, © The Author(s) 2017.
PY - 2017/8/7
Y1 - 2017/8/7
N2 - Tumor necrosis factor α antagonists are increasingly used to treat inflammatory and autoimmune disorders and are associated with increased risk of active tuberculosis. Diagnosis of active tuberculosis in patients taking tumor necrosis factor α antagonists can be challenging owing to increased incidence of extrapulmonary manifestations and false-negative results on current available diagnostic tests. We present a case of a young woman on infliximab for ulcerative colitis who presented with disseminated tuberculosis. As part of a research study, we performed flow cytometric immune profiling, which has previously not been reported in patients with active tuberculosis taking tumor necrosis α antagonists. The flow cytometry results were within the positive thresholds for tuberculosis infection. Flow cytometric immune profiling may be a valid diagnostic tool for patients taking tumor necrosis factor α antagonists.
AB - Tumor necrosis factor α antagonists are increasingly used to treat inflammatory and autoimmune disorders and are associated with increased risk of active tuberculosis. Diagnosis of active tuberculosis in patients taking tumor necrosis factor α antagonists can be challenging owing to increased incidence of extrapulmonary manifestations and false-negative results on current available diagnostic tests. We present a case of a young woman on infliximab for ulcerative colitis who presented with disseminated tuberculosis. As part of a research study, we performed flow cytometric immune profiling, which has previously not been reported in patients with active tuberculosis taking tumor necrosis α antagonists. The flow cytometry results were within the positive thresholds for tuberculosis infection. Flow cytometric immune profiling may be a valid diagnostic tool for patients taking tumor necrosis factor α antagonists.
KW - Tumor necrosis factor alpha antagonists
KW - active tuberculosis
KW - flow cytometry
KW - inflammatory bowel disease
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U2 - 10.1177/1179547617724776
DO - 10.1177/1179547617724776
M3 - Article
AN - SCOPUS:85031746208
SN - 1179-5476
VL - 10
SP - 1
EP - 3
JO - Clinical Medicine Insights: Case Reports
JF - Clinical Medicine Insights: Case Reports
ER -