Flow Cytometric Assessment of Chronic Myeloid Neoplasms

Min Shi; Phuong Nguyen; Dragan Jevremovic

doi:10.1016/j.cll.2017.07.006

Flow Cytometric Assessment of Chronic Myeloid Neoplasms

Min Shi, Phuong Nguyen, Dragan Jevremovic

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Flow cytometry immunophenotyping of the hematopoietic cells from the bone marrow can help with diagnosis, prognosis, and therapy of chronic myeloid neoplasms. Unlike with B-cell neoplasms, there is no simple phenotypic test to substitute for clonality. Therefore, antigen panels to evaluate myeloid neoplasms are larger, and the gating strategies more complex than for lymphoid neoplasms. The number of phenotypic abnormalities in hematopoietic cells correlates with disease severity and cytogenetic complexity, and can be integrated into a scoring system for diagnostic and prognostic purposes. However, flow cytometry remains only an adjunct diagnostic modality.

Original language	English (US)
Pages (from-to)	803-819
Number of pages	17
Journal	Clinics in Laboratory Medicine
Volume	37
Issue number	4
DOIs	https://doi.org/10.1016/j.cll.2017.07.006
State	Published - Dec 2017

Keywords

Diagnosis
Flow cytometry
Myelodysplastic syndrome
Myeloid neoplasm

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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10.1016/j.cll.2017.07.006

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title = "Flow Cytometric Assessment of Chronic Myeloid Neoplasms",

abstract = "Flow cytometry immunophenotyping of the hematopoietic cells from the bone marrow can help with diagnosis, prognosis, and therapy of chronic myeloid neoplasms. Unlike with B-cell neoplasms, there is no simple phenotypic test to substitute for clonality. Therefore, antigen panels to evaluate myeloid neoplasms are larger, and the gating strategies more complex than for lymphoid neoplasms. The number of phenotypic abnormalities in hematopoietic cells correlates with disease severity and cytogenetic complexity, and can be integrated into a scoring system for diagnostic and prognostic purposes. However, flow cytometry remains only an adjunct diagnostic modality.",

keywords = "Diagnosis, Flow cytometry, Myelodysplastic syndrome, Myeloid neoplasm",

author = "Min Shi and Phuong Nguyen and Dragan Jevremovic",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = dec,

doi = "10.1016/j.cll.2017.07.006",

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T1 - Flow Cytometric Assessment of Chronic Myeloid Neoplasms

AU - Shi, Min

AU - Nguyen, Phuong

AU - Jevremovic, Dragan

PY - 2017/12

Y1 - 2017/12

N2 - Flow cytometry immunophenotyping of the hematopoietic cells from the bone marrow can help with diagnosis, prognosis, and therapy of chronic myeloid neoplasms. Unlike with B-cell neoplasms, there is no simple phenotypic test to substitute for clonality. Therefore, antigen panels to evaluate myeloid neoplasms are larger, and the gating strategies more complex than for lymphoid neoplasms. The number of phenotypic abnormalities in hematopoietic cells correlates with disease severity and cytogenetic complexity, and can be integrated into a scoring system for diagnostic and prognostic purposes. However, flow cytometry remains only an adjunct diagnostic modality.

AB - Flow cytometry immunophenotyping of the hematopoietic cells from the bone marrow can help with diagnosis, prognosis, and therapy of chronic myeloid neoplasms. Unlike with B-cell neoplasms, there is no simple phenotypic test to substitute for clonality. Therefore, antigen panels to evaluate myeloid neoplasms are larger, and the gating strategies more complex than for lymphoid neoplasms. The number of phenotypic abnormalities in hematopoietic cells correlates with disease severity and cytogenetic complexity, and can be integrated into a scoring system for diagnostic and prognostic purposes. However, flow cytometry remains only an adjunct diagnostic modality.

KW - Diagnosis

KW - Flow cytometry

KW - Myelodysplastic syndrome

KW - Myeloid neoplasm

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AN - SCOPUS:85029596322

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JO - Clinics in Laboratory Medicine

JF - Clinics in Laboratory Medicine

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ER -

Flow Cytometric Assessment of Chronic Myeloid Neoplasms

Abstract

Keywords

ASJC Scopus subject areas

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