Flow Cytometric Assessment of Chronic Myeloid Neoplasms

Min Shi, Phuong Nguyen, Dragan Jevremovic

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Flow cytometry immunophenotyping of the hematopoietic cells from the bone marrow can help with diagnosis, prognosis, and therapy of chronic myeloid neoplasms. Unlike with B-cell neoplasms, there is no simple phenotypic test to substitute for clonality. Therefore, antigen panels to evaluate myeloid neoplasms are larger, and the gating strategies more complex than for lymphoid neoplasms. The number of phenotypic abnormalities in hematopoietic cells correlates with disease severity and cytogenetic complexity, and can be integrated into a scoring system for diagnostic and prognostic purposes. However, flow cytometry remains only an adjunct diagnostic modality.

Original languageEnglish (US)
Pages (from-to)803-819
Number of pages17
JournalClinics in Laboratory Medicine
Issue number4
StatePublished - Dec 2017


  • Diagnosis
  • Flow cytometry
  • Myelodysplastic syndrome
  • Myeloid neoplasm

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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