Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project

Yi Su; Hillary Protas; Ji Luo; Kewei Chen; Michael L. Alosco; Charles H. Adler; Laura J. Balcer; Charles Bernick; Rhoda Au; Sarah J. Banks; William B. Barr; Michael J. Coleman; David W. Dodick; Douglas I. Katz; Kenneth L. Marek; Michael D. McClean; Ann C. McKee; Jesse Mez; Daniel H. Daneshvar; Joseph N. Palmisano; Elaine R. Peskind; Robert W. Turner; Jennifer V. Wethe; Gil Rabinovici; Keith Johnson; Yorghos Tripodis; Jeffrey L. Cummings; Martha E. Shenton; Robert A. Stern; Eric M. Reiman

doi:10.1002/alz.13602

Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project

Yi Su, Hillary Protas, Ji Luo, Kewei Chen, Michael L. Alosco, Charles H. Adler, Laura J. Balcer, Charles Bernick, Rhoda Au, Sarah J. Banks, William B. Barr, Michael J. Coleman, David W. Dodick, Douglas I. Katz, Kenneth L. Marek, Michael D. McClean, Ann C. McKee, Jesse Mez, Daniel H. Daneshvar, Joseph N. PalmisanoElaine R. Peskind, Robert W. Turner, Jennifer V. Wethe, Gil Rabinovici, Keith Johnson, Yorghos Tripodis, Jeffrey L. Cummings, Martha E. Shenton, Robert A. Stern, Eric M. Reiman

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project. METHOD: We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same-age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES). RESULTS: Significantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p < 0.05). Association between regional flortaucipir uptake and estimated cumulative head impact exposure was only observed in the superior frontal region in former players over 60 years old. Flortaucipir PET was not able to differentiate TES groups. DISCUSSION: Additional studies are needed to further understand tau pathology in CTE and other individuals with a history of RHI.

Original language	English (US)
Pages (from-to)	1827-1838
Number of pages	12
Journal	Alzheimer's and Dementia
Volume	20
Issue number	3
DOIs	https://doi.org/10.1002/alz.13602
State	Published - Mar 2024

Keywords

CTE
PET
Tau
flortaucipir
football

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1002/alz.13602

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Su, Y., Protas, H., Luo, J., Chen, K., Alosco, M. L., Adler, C. H., Balcer, L. J., Bernick, C., Au, R., Banks, S. J., Barr, W. B., Coleman, M. J., Dodick, D. W., Katz, D. I., Marek, K. L., McClean, M. D., McKee, A. C., Mez, J., Daneshvar, D. H., ... Reiman, E. M. (2024). Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project. Alzheimer's and Dementia, 20(3), 1827-1838. https://doi.org/10.1002/alz.13602

Su, Y, Protas, H, Luo, J, Chen, K, Alosco, ML, Adler, CH, Balcer, LJ, Bernick, C, Au, R, Banks, SJ, Barr, WB, Coleman, MJ, Dodick, DW, Katz, DI, Marek, KL, McClean, MD, McKee, AC, Mez, J, Daneshvar, DH, Palmisano, JN, Peskind, ER, Turner, RW, Wethe, JV, Rabinovici, G, Johnson, K, Tripodis, Y, Cummings, JL, Shenton, ME, Stern, RA & Reiman, EM 2024, 'Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project', Alzheimer's and Dementia, vol. 20, no. 3, pp. 1827-1838. https://doi.org/10.1002/alz.13602

@article{f36e8864d0da4958a24cfeb6c13afae2,

title = "Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project",

abstract = "INTRODUCTION: Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project. METHOD: We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same-age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES). RESULTS: Significantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p < 0.05). Association between regional flortaucipir uptake and estimated cumulative head impact exposure was only observed in the superior frontal region in former players over 60 years old. Flortaucipir PET was not able to differentiate TES groups. DISCUSSION: Additional studies are needed to further understand tau pathology in CTE and other individuals with a history of RHI.",

keywords = "CTE, PET, Tau, flortaucipir, football",

author = "Yi Su and Hillary Protas and Ji Luo and Kewei Chen and Alosco, {Michael L.} and Adler, {Charles H.} and Balcer, {Laura J.} and Charles Bernick and Rhoda Au and Banks, {Sarah J.} and Barr, {William B.} and Coleman, {Michael J.} and Dodick, {David W.} and Katz, {Douglas I.} and Marek, {Kenneth L.} and McClean, {Michael D.} and McKee, {Ann C.} and Jesse Mez and Daneshvar, {Daniel H.} and Palmisano, {Joseph N.} and Peskind, {Elaine R.} and Turner, {Robert W.} and Wethe, {Jennifer V.} and Gil Rabinovici and Keith Johnson and Yorghos Tripodis and Cummings, {Jeffrey L.} and Shenton, {Martha E.} and Stern, {Robert A.} and Reiman, {Eric M.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2024",

month = mar,

doi = "10.1002/alz.13602",

language = "English (US)",

volume = "20",

pages = "1827--1838",

journal = "Alzheimer's and Dementia",

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T1 - Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project

AU - Su, Yi

AU - Protas, Hillary

AU - Luo, Ji

AU - Chen, Kewei

AU - Alosco, Michael L.

AU - Adler, Charles H.

AU - Balcer, Laura J.

AU - Bernick, Charles

AU - Au, Rhoda

AU - Banks, Sarah J.

AU - Barr, William B.

AU - Coleman, Michael J.

AU - Dodick, David W.

AU - Katz, Douglas I.

AU - Marek, Kenneth L.

AU - McClean, Michael D.

AU - McKee, Ann C.

AU - Mez, Jesse

AU - Daneshvar, Daniel H.

AU - Palmisano, Joseph N.

AU - Peskind, Elaine R.

AU - Turner, Robert W.

AU - Wethe, Jennifer V.

AU - Rabinovici, Gil

AU - Johnson, Keith

AU - Tripodis, Yorghos

AU - Cummings, Jeffrey L.

AU - Shenton, Martha E.

AU - Stern, Robert A.

AU - Reiman, Eric M.

PY - 2024/3

Y1 - 2024/3

N2 - INTRODUCTION: Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project. METHOD: We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same-age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES). RESULTS: Significantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p < 0.05). Association between regional flortaucipir uptake and estimated cumulative head impact exposure was only observed in the superior frontal region in former players over 60 years old. Flortaucipir PET was not able to differentiate TES groups. DISCUSSION: Additional studies are needed to further understand tau pathology in CTE and other individuals with a history of RHI.

AB - INTRODUCTION: Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project. METHOD: We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same-age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES). RESULTS: Significantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p < 0.05). Association between regional flortaucipir uptake and estimated cumulative head impact exposure was only observed in the superior frontal region in former players over 60 years old. Flortaucipir PET was not able to differentiate TES groups. DISCUSSION: Additional studies are needed to further understand tau pathology in CTE and other individuals with a history of RHI.

KW - CTE

KW - PET

KW - Tau

KW - flortaucipir

KW - football

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SP - 1827

EP - 1838

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 3

ER -

Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project

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