Flat adenomas in a colon cancer-prone kindred

Henry T. Lynch, Tom Smyrk, Stephen J. Lanspa, Joseph N. Marcus, Mary Kriegler, Jane F. Lynch, Henry D. Appelman

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


We describe new pathologic findings in a hereditary nonpolyposis colorectal cancer family. Affected family members developed multiple small adenomas with right-sided predominance; many adenomas had an unusual appearance featuring slightly elevated lesions with adenomatous changes confined to the upper regions of the colonic crypts. We have adopted the previously established term "flat adenoma" for these lesions. This phenotype may be a morphologic marker for at least one subset of hereditary nonpolyposis colorectal cancer. [J Natl Cancer Inst 1988;80:278-282].

Original languageEnglish (US)
Pages (from-to)278-282
Number of pages5
JournalJournal of the National Cancer Institute
Issue number4
StatePublished - Apr 20 1988

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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