Five-year mortality after transient ischemic attack focus on cardiometabolic comorbidity and hospital readmission

Mohammed Yousufuddin, Nathan Young, Lawrence Keenan, Tammy Olson, Jessica Shultz, Taylor Doyle, Eimad M. Ahmmad, Kogulavadanan Arumaithurai, Paul Takahashi, Mohammad Hassan Murad

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background and Purpose-We aimed at providing estimates of mortality associated with cardiometabolic comorbidity and incident readmission from cardiometabolic as compared with noncardiometabolic conditions after a frst transient ischemic attack. Methods-Between 2000 and 2015, patients hospitalized for a frst transient ischemic attack were examined for cardiometabolic comorbidities (diabetes mellitus, coronary artery disease, heart failure, and atrial fbrillation), 5-year incident hospitalization, and time to death. Results-Of 251 patients with transient ischemic attack, 134 (53%) had at least 1 and 55 (22%) had at least 2 cardiometabolic conditions. By 5 years, 491 readmissions (134 [27%] cardiometabolic and 357 [73%] noncardiometabolic) and 75 deaths (27 [36%] cardiometabolic and 47 [64%] noncardiometabolic) were observed. Mortality was increased with any concurrent cardiometabolic comorbidity (hazard ratio, 1.89; 95% confdence interval, 1.17-3.03; P=0.0089) with multiplicative mortality risk from a combination of coronary artery disease and heart failure. Each hospitalization was associated with a 1.5-fold risk of death (95% confdence interval, 1.37-1.64; P<0.0001). Risk of cardiometabolic and noncardiometabolic mortality was correlated with the corresponding category-specifc readmission. Conclusions-Among patients hospitalized for frst transient ischemic attack, 5-year mortality is associated with concurrent cardiometabolic comorbidity and rates of subsequent hospitalization.

Original languageEnglish (US)
Pages (from-to)730-733
Number of pages4
Issue number3
StatePublished - 2018


  • Confdence interval
  • Heart failure
  • Humans
  • Ischemic attack, transient
  • Mortality

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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