FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia

Ayalew Tefferi; Terra L. Lasho; Stephanie R. Brockman; Michelle A. Elliott; Angela Dispenzieri; Animesh Pardanani

FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia

Ayalew Tefferi, Terra L. Lasho, Stephanie R. Brockman, Michelle A. Elliott, Angela Dispenzieri, Animesh Pardanani

Hematology

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Laboratory methods to detect both FIP1L1-PDGFRA and c-kit D816V mutations were combined with immunomagnetic cell separation to study the extent of clonal involvement by both myeloid and lymphoid cells in 3 patients with systemic mastocytosis associated with eosinophilia. The results suggested an early stem cell origin for the FIP1L1-PDGFRA mutation.

Original language	English (US)
Pages (from-to)	871-873
Number of pages	3
Journal	Haematologica
Volume	89
Issue number	7
State	Published - Jul 1 2004

Keywords

Eosinophilia
Mastocytosis
Mutations
Systemic mast cell disease

ASJC Scopus subject areas

Hematology

Cite this

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abstract = "Laboratory methods to detect both FIP1L1-PDGFRA and c-kit D816V mutations were combined with immunomagnetic cell separation to study the extent of clonal involvement by both myeloid and lymphoid cells in 3 patients with systemic mastocytosis associated with eosinophilia. The results suggested an early stem cell origin for the FIP1L1-PDGFRA mutation.",

keywords = "Eosinophilia, Mastocytosis, Mutations, Systemic mast cell disease",

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T1 - FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia

AU - Tefferi, Ayalew

AU - Lasho, Terra L.

AU - Brockman, Stephanie R.

AU - Elliott, Michelle A.

AU - Dispenzieri, Angela

AU - Pardanani, Animesh

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Laboratory methods to detect both FIP1L1-PDGFRA and c-kit D816V mutations were combined with immunomagnetic cell separation to study the extent of clonal involvement by both myeloid and lymphoid cells in 3 patients with systemic mastocytosis associated with eosinophilia. The results suggested an early stem cell origin for the FIP1L1-PDGFRA mutation.

AB - Laboratory methods to detect both FIP1L1-PDGFRA and c-kit D816V mutations were combined with immunomagnetic cell separation to study the extent of clonal involvement by both myeloid and lymphoid cells in 3 patients with systemic mastocytosis associated with eosinophilia. The results suggested an early stem cell origin for the FIP1L1-PDGFRA mutation.

KW - Eosinophilia

KW - Mastocytosis

KW - Mutations

KW - Systemic mast cell disease

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SN - 0390-6078

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JO - Haematologica

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IS - 7

ER -

FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia

Abstract

Keywords

ASJC Scopus subject areas

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