@article{2d9ecdf0108b496abcfdf32f70701274,
title = "Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis",
abstract = "Curtis et al. show that metastasizing ovarian cancer cells can mobilize glycogen as an energy source, leading to increased proliferation, invasion, and metastasis, following their interaction with cancer-associated fibroblasts (CAFs). This process is dependent on p38α MAPK activation in CAFs and inhibition of the pathway reduced metastatic tumor growth in vivo.",
keywords = "PGM1, cancer-associated fibroblast, glycogen, glycogen phosphorylase, metabolism, metastasis, omentum, ovarian cancer, p38-MAPK, phosphoproteomics",
author = "Marion Curtis and Kenny, {Hilary A.} and Bradley Ashcroft and Abir Mukherjee and Alyssa Johnson and Yilin Zhang and Ynes Helou and Raquel Batlle and Xiaojing Liu and Nuria Gutierrez and Xia Gao and Yamada, {S. Diane} and Ricardo Lastra and Anthony Montag and Nagib Ahsan and Locasale, {Jason W.} and Salomon, {Arthur R.} and Nebreda, {Angel R.} and Ernst Lengyel",
note = "Funding Information: We are very grateful to Phoebe Rice, PhD, Department of Biochemistry, University of Chicago, for in silico modeling of the PGM1 protein; and Elisabet Llonch, IRB Barcelona, for phospho-p38 immunohistochemistry. We are very thankful to Gail Isenberg, University of Chicago, for editing the manuscript. This work was supported by the Cancer Research Foundation Fletcher Scholars Program, Bears Care, the charitable beneficiary of the Chicago Bears Football Club, and the National Cancer Institute grant R01 CA169604 (E.L.); and R01 CA193256 , R00CA168997 , and R21CA201963 (J.W.L). A.R.N's research group was supported by the European Commission grant ERC 294665 . We acknowledge the University of Chicago Human Tissue Resource Center for PAS staining funded by the Cancer Center Support Grant ( P30CA014599 ) as well as the University of Chicago Advanced Electron Microscopy Core Facility for transmission electron microscopy. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "8",
doi = "10.1016/j.cmet.2018.08.007",
language = "English (US)",
volume = "29",
pages = "141--155.e9",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "1",
}