Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

Marion Curtis; Hilary A. Kenny; Bradley Ashcroft; Abir Mukherjee; Alyssa Johnson; Yilin Zhang; Ynes Helou; Raquel Batlle; Xiaojing Liu; Nuria Gutierrez; Xia Gao; S. Diane Yamada; Ricardo Lastra; Anthony Montag; Nagib Ahsan; Jason W. Locasale; Arthur R. Salomon; Angel R. Nebreda; Ernst Lengyel

doi:10.1016/j.cmet.2018.08.007

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

Marion Curtis, Hilary A. Kenny, Bradley Ashcroft, Abir Mukherjee, Alyssa Johnson, Yilin Zhang, Ynes Helou, Raquel Batlle, Xiaojing Liu, Nuria Gutierrez, Xia Gao, S. Diane Yamada, Ricardo Lastra, Anthony Montag, Nagib Ahsan, Jason W. Locasale, Arthur R. Salomon, Angel R. Nebreda, Ernst Lengyel

Allergy, Asthma and Clinical Immunology

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Curtis et al. show that metastasizing ovarian cancer cells can mobilize glycogen as an energy source, leading to increased proliferation, invasion, and metastasis, following their interaction with cancer-associated fibroblasts (CAFs). This process is dependent on p38α MAPK activation in CAFs and inhibition of the pathway reduced metastatic tumor growth in vivo.

Original language	English (US)
Pages (from-to)	141-155.e9
Journal	Cell Metabolism
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2018.08.007
State	Published - Jan 8 2019

Keywords

PGM1
cancer-associated fibroblast
glycogen
glycogen phosphorylase
metabolism
metastasis
omentum
ovarian cancer
p38-MAPK
phosphoproteomics

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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Curtis, M., Kenny, H. A., Ashcroft, B., Mukherjee, A., Johnson, A., Zhang, Y., Helou, Y., Batlle, R., Liu, X., Gutierrez, N., Gao, X., Yamada, S. D., Lastra, R., Montag, A., Ahsan, N., Locasale, J. W., Salomon, A. R., Nebreda, A. R., & Lengyel, E. (2019). Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. Cell Metabolism, 29(1), 141-155.e9. https://doi.org/10.1016/j.cmet.2018.08.007

Curtis, M, Kenny, HA, Ashcroft, B, Mukherjee, A, Johnson, A, Zhang, Y, Helou, Y, Batlle, R, Liu, X, Gutierrez, N, Gao, X, Yamada, SD, Lastra, R, Montag, A, Ahsan, N, Locasale, JW, Salomon, AR, Nebreda, AR & Lengyel, E 2019, 'Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis', Cell Metabolism, vol. 29, no. 1, pp. 141-155.e9. https://doi.org/10.1016/j.cmet.2018.08.007

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title = "Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis",

abstract = "Curtis et al. show that metastasizing ovarian cancer cells can mobilize glycogen as an energy source, leading to increased proliferation, invasion, and metastasis, following their interaction with cancer-associated fibroblasts (CAFs). This process is dependent on p38α MAPK activation in CAFs and inhibition of the pathway reduced metastatic tumor growth in vivo.",

keywords = "PGM1, cancer-associated fibroblast, glycogen, glycogen phosphorylase, metabolism, metastasis, omentum, ovarian cancer, p38-MAPK, phosphoproteomics",

author = "Marion Curtis and Kenny, {Hilary A.} and Bradley Ashcroft and Abir Mukherjee and Alyssa Johnson and Yilin Zhang and Ynes Helou and Raquel Batlle and Xiaojing Liu and Nuria Gutierrez and Xia Gao and Yamada, {S. Diane} and Ricardo Lastra and Anthony Montag and Nagib Ahsan and Locasale, {Jason W.} and Salomon, {Arthur R.} and Nebreda, {Angel R.} and Ernst Lengyel",

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doi = "10.1016/j.cmet.2018.08.007",

language = "English (US)",

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AU - Curtis, Marion

AU - Kenny, Hilary A.

AU - Ashcroft, Bradley

AU - Mukherjee, Abir

AU - Johnson, Alyssa

AU - Zhang, Yilin

AU - Helou, Ynes

AU - Batlle, Raquel

AU - Liu, Xiaojing

AU - Gutierrez, Nuria

AU - Gao, Xia

AU - Yamada, S. Diane

AU - Lastra, Ricardo

AU - Montag, Anthony

AU - Ahsan, Nagib

AU - Locasale, Jason W.

AU - Salomon, Arthur R.

AU - Nebreda, Angel R.

AU - Lengyel, Ernst

PY - 2019/1/8

Y1 - 2019/1/8

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AB - Curtis et al. show that metastasizing ovarian cancer cells can mobilize glycogen as an energy source, leading to increased proliferation, invasion, and metastasis, following their interaction with cancer-associated fibroblasts (CAFs). This process is dependent on p38α MAPK activation in CAFs and inhibition of the pathway reduced metastatic tumor growth in vivo.

KW - PGM1

KW - cancer-associated fibroblast

KW - glycogen

KW - glycogen phosphorylase

KW - metabolism

KW - metastasis

KW - omentum

KW - ovarian cancer

KW - p38-MAPK

KW - phosphoproteomics

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JO - Cell Metabolism

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Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

Abstract

Keywords

ASJC Scopus subject areas

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