Familial Pancreatic Adenocarcinoma

Gloria M. Petersen

doi:10.1016/j.hoc.2015.04.007

Familial Pancreatic Adenocarcinoma

Gloria M. Petersen

Quantitative Health Sciences

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Familial pancreatic cancer (FPC) kindreds have at least 2 first-degree relatives with pancreatic ductal adenocarcinoma. Studies of FPC have focused on the discovery of genetic cause and on the management of those at genetically high risk. Research reveals that a half dozen known hereditary syndromes or genes are associated with increased risk of developing pancreatic cancer, the most prominent of which are BRCA2 and CDKN2A. Genetic risk assessment and testing is already available. Owing to limited experience worldwide, guidance is often based on expert opinion, although all agree that research is needed to improve the shaping of options.

Original language	English (US)
Pages (from-to)	641-653
Number of pages	13
Journal	Hematology/Oncology Clinics of North America
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.hoc.2015.04.007
State	Published - Aug 1 2015

Keywords

Familial risk
Genetic susceptibility
Genetic testing
Risk assessment and management

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.hoc.2015.04.007

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title = "Familial Pancreatic Adenocarcinoma",

abstract = "Familial pancreatic cancer (FPC) kindreds have at least 2 first-degree relatives with pancreatic ductal adenocarcinoma. Studies of FPC have focused on the discovery of genetic cause and on the management of those at genetically high risk. Research reveals that a half dozen known hereditary syndromes or genes are associated with increased risk of developing pancreatic cancer, the most prominent of which are BRCA2 and CDKN2A. Genetic risk assessment and testing is already available. Owing to limited experience worldwide, guidance is often based on expert opinion, although all agree that research is needed to improve the shaping of options.",

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N2 - Familial pancreatic cancer (FPC) kindreds have at least 2 first-degree relatives with pancreatic ductal adenocarcinoma. Studies of FPC have focused on the discovery of genetic cause and on the management of those at genetically high risk. Research reveals that a half dozen known hereditary syndromes or genes are associated with increased risk of developing pancreatic cancer, the most prominent of which are BRCA2 and CDKN2A. Genetic risk assessment and testing is already available. Owing to limited experience worldwide, guidance is often based on expert opinion, although all agree that research is needed to improve the shaping of options.

AB - Familial pancreatic cancer (FPC) kindreds have at least 2 first-degree relatives with pancreatic ductal adenocarcinoma. Studies of FPC have focused on the discovery of genetic cause and on the management of those at genetically high risk. Research reveals that a half dozen known hereditary syndromes or genes are associated with increased risk of developing pancreatic cancer, the most prominent of which are BRCA2 and CDKN2A. Genetic risk assessment and testing is already available. Owing to limited experience worldwide, guidance is often based on expert opinion, although all agree that research is needed to improve the shaping of options.

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KW - Genetic testing

KW - Risk assessment and management

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Familial Pancreatic Adenocarcinoma

Abstract

Keywords

ASJC Scopus subject areas

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