Failure to Confirm Muscarinic Receptors on Skin Fibroblasts

Robert H. Lenox; Robert J. Hitzemann; Elliott Richelson; John R. Kelsoe; John R. Kelsoe; J. Christian Gillin; David S. Janowsky; Joan Heller Brown; S. Craig Risch; Barry Lumkin; Elliot S. Gershon; N. Suzan Nadi; John I. Nurnberger; Wade H. Berrettini

doi:10.1056/NEJM198503283121319

Failure to Confirm Muscarinic Receptors on Skin Fibroblasts

Robert H. Lenox, Robert J. Hitzemann, Elliott Richelson, John R. Kelsoe, John R. Kelsoe, J. Christian Gillin, David S. Janowsky, Joan Heller Brown, S. Craig Risch, Barry Lumkin, Elliot S. Gershon, N. Suzan Nadi, John I. Nurnberger, Wade H. Berrettini

Neuroscience

Research output: Contribution to journal › Letter › peer-review

15 Scopus citations

Abstract

To the Editor: In the July 26 issue, Nadi et al.¹ reported that primary cultures of human skin fibroblasts “possess muscarinic receptors with the properties of specific binding, saturability, pharmacologic specificity, inhibition of norepinephrine-stimulated adenylate cyclase, and increased binding after incubation with an antagonist.” The authors also indicated that the fibroblasts of patients with a major affective disorder (or a relative with a history of a major or minor depressive disorder) had a significantly higher density of muscarinic binding sites as determined by the binding of the radioactive antagonist ligand [³H]quinuclidinyl benzilate ([³H]QNB) than did control subjects. They.

Original language	English (US)
Pages (from-to)	861-862
Number of pages	2
Journal	New England Journal of Medicine
Volume	312
Issue number	13
DOIs	https://doi.org/10.1056/NEJM198503283121319
State	Published - Mar 28 1985

ASJC Scopus subject areas

Medicine(all)

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Lenox, R. H., Hitzemann, R. J., Richelson, E., Kelsoe, J. R., Kelsoe, J. R., Gillin, J. C., Janowsky, D. S., Brown, J. H., Risch, S. C., Lumkin, B., Gershon, E. S., Nadi, N. S., Nurnberger, J. I., & Berrettini, W. H. (1985). Failure to Confirm Muscarinic Receptors on Skin Fibroblasts. New England Journal of Medicine, 312(13), 861-862. https://doi.org/10.1056/NEJM198503283121319

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title = "Failure to Confirm Muscarinic Receptors on Skin Fibroblasts",

abstract = "To the Editor: In the July 26 issue, Nadi et al.1 reported that primary cultures of human skin fibroblasts “possess muscarinic receptors with the properties of specific binding, saturability, pharmacologic specificity, inhibition of norepinephrine-stimulated adenylate cyclase, and increased binding after incubation with an antagonist.” The authors also indicated that the fibroblasts of patients with a major affective disorder (or a relative with a history of a major or minor depressive disorder) had a significantly higher density of muscarinic binding sites as determined by the binding of the radioactive antagonist ligand [3H]quinuclidinyl benzilate ([3H]QNB) than did control subjects. They.",

author = "Lenox, {Robert H.} and Hitzemann, {Robert J.} and Elliott Richelson and Kelsoe, {John R.} and Kelsoe, {John R.} and Gillin, {J. Christian} and Janowsky, {David S.} and Brown, {Joan Heller} and Risch, {S. Craig} and Barry Lumkin and Gershon, {Elliot S.} and Nadi, {N. Suzan} and Nurnberger, {John I.} and Berrettini, {Wade H.}",

year = "1985",

month = mar,

day = "28",

doi = "10.1056/NEJM198503283121319",

language = "English (US)",

volume = "312",

pages = "861--862",

journal = "New England Journal of Medicine",

issn = "0028-4793",

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TY - JOUR

T1 - Failure to Confirm Muscarinic Receptors on Skin Fibroblasts

AU - Lenox, Robert H.

AU - Hitzemann, Robert J.

AU - Richelson, Elliott

AU - Kelsoe, John R.

AU - Gillin, J. Christian

AU - Janowsky, David S.

AU - Brown, Joan Heller

AU - Risch, S. Craig

AU - Lumkin, Barry

AU - Gershon, Elliot S.

AU - Nadi, N. Suzan

AU - Nurnberger, John I.

AU - Berrettini, Wade H.

PY - 1985/3/28

Y1 - 1985/3/28

N2 - To the Editor: In the July 26 issue, Nadi et al.1 reported that primary cultures of human skin fibroblasts “possess muscarinic receptors with the properties of specific binding, saturability, pharmacologic specificity, inhibition of norepinephrine-stimulated adenylate cyclase, and increased binding after incubation with an antagonist.” The authors also indicated that the fibroblasts of patients with a major affective disorder (or a relative with a history of a major or minor depressive disorder) had a significantly higher density of muscarinic binding sites as determined by the binding of the radioactive antagonist ligand [3H]quinuclidinyl benzilate ([3H]QNB) than did control subjects. They.

AB - To the Editor: In the July 26 issue, Nadi et al.1 reported that primary cultures of human skin fibroblasts “possess muscarinic receptors with the properties of specific binding, saturability, pharmacologic specificity, inhibition of norepinephrine-stimulated adenylate cyclase, and increased binding after incubation with an antagonist.” The authors also indicated that the fibroblasts of patients with a major affective disorder (or a relative with a history of a major or minor depressive disorder) had a significantly higher density of muscarinic binding sites as determined by the binding of the radioactive antagonist ligand [3H]quinuclidinyl benzilate ([3H]QNB) than did control subjects. They.

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U2 - 10.1056/NEJM198503283121319

DO - 10.1056/NEJM198503283121319

M3 - Letter

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AN - SCOPUS:0021993519

SN - 0028-4793

VL - 312

SP - 861

EP - 862

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 13

ER -

Failure to Confirm Muscarinic Receptors on Skin Fibroblasts

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