Failure of methylprednisolone acetate to prolong the antinauseant effect of intravenous methylprednisolone sodium succinate in patients receiving chemotherapy

D. Osoba; C. Erlichman; A. R. Willan; M. L. Brigden; P. Geggie; J. L. Pater; J. J. Rusthoven; K. S. Wilson

Failure of methylprednisolone acetate to prolong the antinauseant effect of intravenous methylprednisolone sodium succinate in patients receiving chemotherapy

D. Osoba, C. Erlichman, A. R. Willan, M. L. Brigden, P. Geggie, J. L. Pater, J. J. Rusthoven, K. S. Wilson

Medical Oncology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The efficacy of intramuscular methylprednisolone acetate in maintaining the antinauseant effect of intravenous methylprednisolone sodium succinate was assessed in a prospectively-randomized, double-blind, crossover-design trial. Of 150 patients entered, 127 were evaluable. There was no statistically significant difference between methylprednisolone acetate and saline placebo, although patient preferences slightly favoured the methylprednisolone acetate for nausea, vomiting, and overall effectiveness.

Original language	English (US)
Pages (from-to)	377-379
Number of pages	3
Journal	Clinical and Investigative Medicine
Volume	11
Issue number	5
State	Published - 1988

ASJC Scopus subject areas

General Medicine

Cite this

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abstract = "The efficacy of intramuscular methylprednisolone acetate in maintaining the antinauseant effect of intravenous methylprednisolone sodium succinate was assessed in a prospectively-randomized, double-blind, crossover-design trial. Of 150 patients entered, 127 were evaluable. There was no statistically significant difference between methylprednisolone acetate and saline placebo, although patient preferences slightly favoured the methylprednisolone acetate for nausea, vomiting, and overall effectiveness.",

author = "D. Osoba and C. Erlichman and Willan, {A. R.} and Brigden, {M. L.} and P. Geggie and Pater, {J. L.} and Rusthoven, {J. J.} and Wilson, {K. S.}",

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AU - Osoba, D.

AU - Erlichman, C.

AU - Willan, A. R.

AU - Brigden, M. L.

AU - Geggie, P.

AU - Pater, J. L.

AU - Rusthoven, J. J.

AU - Wilson, K. S.

PY - 1988

Y1 - 1988

N2 - The efficacy of intramuscular methylprednisolone acetate in maintaining the antinauseant effect of intravenous methylprednisolone sodium succinate was assessed in a prospectively-randomized, double-blind, crossover-design trial. Of 150 patients entered, 127 were evaluable. There was no statistically significant difference between methylprednisolone acetate and saline placebo, although patient preferences slightly favoured the methylprednisolone acetate for nausea, vomiting, and overall effectiveness.

AB - The efficacy of intramuscular methylprednisolone acetate in maintaining the antinauseant effect of intravenous methylprednisolone sodium succinate was assessed in a prospectively-randomized, double-blind, crossover-design trial. Of 150 patients entered, 127 were evaluable. There was no statistically significant difference between methylprednisolone acetate and saline placebo, although patient preferences slightly favoured the methylprednisolone acetate for nausea, vomiting, and overall effectiveness.

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Failure of methylprednisolone acetate to prolong the antinauseant effect of intravenous methylprednisolone sodium succinate in patients receiving chemotherapy

Abstract

ASJC Scopus subject areas

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