Facile syntheses of functionalized toll-like receptor 7 agonists

Babatope Akinbobuyi, Matthew R. Byrd, Charles A. Chang, Mysa Nguyen, Zacharie J. Seifert, Anne Laure Flamar, Gerard Zurawski, Katherine C. Upchurch, Sangkon Oh, Stephen H. Dempsey, Thomas J. Enke, John Le, Hunter J. Winstead, José R. Boquín, Robert R. Kane

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity.

Original languageEnglish (US)
Pages (from-to)458-460
Number of pages3
JournalTetrahedron Letters
Issue number2
StatePublished - Jan 8 2015


  • Adenine derivatives
  • Immune activation
  • Toll-like receptor
  • Vaccines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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