TY - JOUR
T1 - Eyelid Melanoma in the United States
T2 - A National Cancer Database Analysis
AU - Oliver, Jeremie D.
AU - Boczar, Daniel
AU - Sisti, Andrea
AU - Huayllani, Maria T.
AU - Restrepo, David J.
AU - Spaulding, Aaron C.
AU - Gabriel, Emmanuel
AU - Bagaria, Sanjay
AU - Rinker, Brian D.
AU - Forte, Antonio J.
N1 - Funding Information:
This work was supported by the German Human Genome Project 01KW9922/2, DFG 1492/6-1 and Else Kröner-Fresenius Foundation to M.K. and Deutsche Forschungsgemeinschaft SFB 405/D10 to H.J.G. We thank K. Specht for the kind provision of the RNA isolation protocol and helpful discussion, and C. Schmidt, M. Bonrouhi and K. Frach for excellent technical assistance.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - BACKGROUND: Eyelid melanoma (EM) is a rare condition that accounts for <1% of all cutaneous melanomas. In this analysis, patients diagnosed with EM in the United States were compared to those with other melanomas in the head and neck. METHODS: The National Cancer Database was used to select patients with head and neck melanoma from 2004 to 2015. RESULTS: A total of 137,233 patients met the criteria of the study. Among them, 2694 were diagnosed with EM (2%) and 134,539 in other head and neck locations (98%). Regarding the patients with EM, the mean age was 68.56 years (standard deviation 14.04). A greater number of them were treated in Academic/Research Programs (53.6%), insured by Medicare (55.7%), tumor in situ (52.2%), stage 0 (49%), and without ulceration (75.9%). The mean time to treatment commencement was 18.96 days for EM compared to 14.4 days for other melanoma in the head and neck regions (P < 0.001). There was a greater proportion of EM in female patients (odds ratio [OR] 2.371 [2.191-2.566], P < 0.001), compared to male; age greater than 80 years (OR 1.622 [1.360-1.934], P < 0.001) compared to 0 to 49 years. Moreover, EM was an independent predictor for treatment in Academic/Research Programs (OR 1.258 [1.160-1.365], P < 0.001) and diagnosis at autopsy (OR 1.414 [1.083-1.847], P = 0.011) compared to other melanoma in the head and neck region. CONCLUSION: These novel findings have the potential to guide clinical decision making in head and neck melanoma management.
AB - BACKGROUND: Eyelid melanoma (EM) is a rare condition that accounts for <1% of all cutaneous melanomas. In this analysis, patients diagnosed with EM in the United States were compared to those with other melanomas in the head and neck. METHODS: The National Cancer Database was used to select patients with head and neck melanoma from 2004 to 2015. RESULTS: A total of 137,233 patients met the criteria of the study. Among them, 2694 were diagnosed with EM (2%) and 134,539 in other head and neck locations (98%). Regarding the patients with EM, the mean age was 68.56 years (standard deviation 14.04). A greater number of them were treated in Academic/Research Programs (53.6%), insured by Medicare (55.7%), tumor in situ (52.2%), stage 0 (49%), and without ulceration (75.9%). The mean time to treatment commencement was 18.96 days for EM compared to 14.4 days for other melanoma in the head and neck regions (P < 0.001). There was a greater proportion of EM in female patients (odds ratio [OR] 2.371 [2.191-2.566], P < 0.001), compared to male; age greater than 80 years (OR 1.622 [1.360-1.934], P < 0.001) compared to 0 to 49 years. Moreover, EM was an independent predictor for treatment in Academic/Research Programs (OR 1.258 [1.160-1.365], P < 0.001) and diagnosis at autopsy (OR 1.414 [1.083-1.847], P = 0.011) compared to other melanoma in the head and neck region. CONCLUSION: These novel findings have the potential to guide clinical decision making in head and neck melanoma management.
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U2 - 10.1097/SCS.0000000000005673
DO - 10.1097/SCS.0000000000005673
M3 - Article
C2 - 31233000
AN - SCOPUS:85074552757
SN - 1049-2275
VL - 30
SP - 2412
EP - 2415
JO - The Journal of craniofacial surgery
JF - The Journal of craniofacial surgery
IS - 8
ER -