Extramedullary disease in multiple myeloma

Radhika Bansal, Sagar Rakshit, Shaji Kumar

Research output: Contribution to journalReview articlepeer-review


When clonal plasma cells grow at anatomic sites distant from the bone marrow or grows contiguous from osseous lesions that break through the cortical bone, it is referred to as extramedullary multiple myeloma (EMD). EMD remains challenging from a therapeutic and biological perspective. The pathogenetic mechanisms are not completely understood and it is generally associated with high-risk cytogenetics which portends poor outcomes. There is a rising incidence of EMD in the era of novel agents, likely a reflection of longer OS, with no standard treatment approach. Patients benefit from aggressive chemotherapy-based approaches, but the OS and prognosis remains poor. RT has been used for palliative care. There is a need for large prospective trials for development of treatment approaches for treatment of EMD.

Original languageEnglish (US)
Article number161
JournalBlood cancer journal
Issue number9
StatePublished - Sep 2021

ASJC Scopus subject areas

  • Hematology
  • Oncology


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