Extraintestinal Consequences of Mucosal Inflammation

Leonidas A. Bourikas, Konstantinos A. Papadakis

Research output: Chapter in Book/Report/Conference proceedingChapter


Constitutional symptoms such as fatigue, anorexia, fever and arthralgias are the result of the systemic effects ofproinflammatory cytokines produced in the IBD mucosa. Anemia frequently complicates the course of IBD and is usually multifactorial with iron deficiency, vitamin B12deficiency, anemia of inflammation, medications or combinations of these being the most common causes. IBD is characterized by a hypercoagulable state and patients are at risk of developing thromboembolic events. IBD carries a higher risk of hematologic malignancies, particularly lymphoma, in patients receiving immunosuppressiveor anti-TNF treatment. Amyloidosis may rarely complicate the course of IBD.

Original languageEnglish (US)
Title of host publicationInflammatory Bowel Disease
Subtitle of host publicationTranslating basic science into clinical practice
Number of pages17
ISBN (Print)9781405157254
StatePublished - May 18 2010


  • Acute phase proteins - 25% increase or decrease in plasma concentrations during inflammation
  • Amyloidosis in patients with IBD
  • Disorders of coagulation - one in 1000 people experiencing thrombotic episode
  • Extraintestinal consequences of mucosal inflammation
  • Hematologic consequences of intestinal inflammation
  • Hematologic malignancies - lymphoma, rheumatoid arthritis, sjögren syndrome or celiac disease
  • Leukocytosis - elevated leukocyte counts associated with increased risk of recurrence

ASJC Scopus subject areas

  • General Medicine


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