TY - JOUR
T1 - Extracellular vesicles in the glioblastoma microenvironment
T2 - A diagnostic and therapeutic perspective
AU - Russo, Marissa N.
AU - Whaley, Lauren A.
AU - Norton, Emily S.
AU - Zarco, Natanael
AU - Guerrero-Cázares, Hugo
N1 - Publisher Copyright:
© 2022
PY - 2023/6
Y1 - 2023/6
N2 - Glioblastoma (GBM), is the most malignant form of gliomas and the most common and lethal primary brain tumor in adults. Conventional cancer treatments have limited to no efficacy on GBM. GBM cells respond and adapt to the surrounding brain parenchyma known as tumor microenvironment (TME) to promote tumor preservation. Among specific TME, there are 3 of particular interest for GBM biology: the perivascular niche, the subventricular zone neurogenic niche, and the immune microenvironment. GBM cells and TME cells present a reciprocal feedback which results in tumor maintenance. One way that these cells can communicate is through extracellular vesicles. These vesicles include exosomes and microvesicles that have the ability to carry both cancerous and non-cancerous cargo, such as miRNA, RNA, proteins, lipids, and DNA. In this review we will discuss the booming topic that is extracellular vesicles, and how they have the novelty to be a diagnostic and targetable vehicle for GBM.
AB - Glioblastoma (GBM), is the most malignant form of gliomas and the most common and lethal primary brain tumor in adults. Conventional cancer treatments have limited to no efficacy on GBM. GBM cells respond and adapt to the surrounding brain parenchyma known as tumor microenvironment (TME) to promote tumor preservation. Among specific TME, there are 3 of particular interest for GBM biology: the perivascular niche, the subventricular zone neurogenic niche, and the immune microenvironment. GBM cells and TME cells present a reciprocal feedback which results in tumor maintenance. One way that these cells can communicate is through extracellular vesicles. These vesicles include exosomes and microvesicles that have the ability to carry both cancerous and non-cancerous cargo, such as miRNA, RNA, proteins, lipids, and DNA. In this review we will discuss the booming topic that is extracellular vesicles, and how they have the novelty to be a diagnostic and targetable vehicle for GBM.
KW - Exosomes
KW - Glioblastoma multiforme
KW - Microvesicles
KW - Perivascular niche
KW - Subventricular zone/neurogenic niche
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85144940016&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85144940016&partnerID=8YFLogxK
U2 - 10.1016/j.mam.2022.101167
DO - 10.1016/j.mam.2022.101167
M3 - Review article
C2 - 36577547
AN - SCOPUS:85144940016
SN - 0098-2997
VL - 91
JO - Molecular Aspects of Medicine
JF - Molecular Aspects of Medicine
M1 - 101167
ER -