TY - JOUR
T1 - Extra-hepatic hepatocellular carcinoma presenting as obstructive jaundice
AU - Batsis, J. A.
AU - Halfdanarson, T. R.
AU - Pitot, H.
PY - 2006/10
Y1 - 2006/10
N2 - Hepatocellular carcinoma is a neoplasm with a uniformly poor prognosis. Risk factors for its development include chronic hepatitis B or C infection, haemochromatosis and α-1-antitrypsin deficiency, but individuals with any type of chronic liver disease are predisposed. The incidence is significantly higher in Asia and Africa although it has been noted to be increasing in the United States. We present a patient with notable atypical clinical features for hepatocellular carcinoma. The patient had neither predisposing risk factors nor a primary liver lesion causing obstructive jaundice. After multiple tissue specimens were obtained, the final pathological diagnosis was established. Hepatocellular carcinoma generally requires a surgical cure, but patients who are icteric often portend poorer prognoses. For those at high risk, screening may be indicated to identify early curative treatment.
AB - Hepatocellular carcinoma is a neoplasm with a uniformly poor prognosis. Risk factors for its development include chronic hepatitis B or C infection, haemochromatosis and α-1-antitrypsin deficiency, but individuals with any type of chronic liver disease are predisposed. The incidence is significantly higher in Asia and Africa although it has been noted to be increasing in the United States. We present a patient with notable atypical clinical features for hepatocellular carcinoma. The patient had neither predisposing risk factors nor a primary liver lesion causing obstructive jaundice. After multiple tissue specimens were obtained, the final pathological diagnosis was established. Hepatocellular carcinoma generally requires a surgical cure, but patients who are icteric often portend poorer prognoses. For those at high risk, screening may be indicated to identify early curative treatment.
KW - Hepatocellular carcinoma
KW - Lymphadenopathy
KW - Metastases
KW - Obstructive jaundice
UR - http://www.scopus.com/inward/record.url?scp=33748498027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748498027&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2005.09.012
DO - 10.1016/j.dld.2005.09.012
M3 - Article
C2 - 16243009
AN - SCOPUS:33748498027
SN - 1590-8658
VL - 38
SP - 768
EP - 771
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 10
ER -