TY - JOUR
T1 - Expression of individual ia specificities T and B cells
T2 - I. Studies with mitogen-induced blast cells*
AU - David, Chella
AU - Meo, Tommaso
AU - McCormick, John
AU - Shreffler, Donald
PY - 1976/1/1
Y1 - 1976/1/1
N2 - Ia specificities 1-10 were detected on LPS-stimulated splenic lymphocytes and on Con A-stimulated spleen, lymph node, and thymus blasts by direct cytotoxic tests. Since Ia antigens are not readily detectable on resting thymocytes, our results suggest that T cells require some signal before they exhibit full expression of Ia specificities. Absorption-elution studies indicated that most of the Ia specificities detected on T and B cells may be identical. Ia antigens detected by homologous antisera gave much stronger reactions than those detected by crossreacting antisera.
AB - Ia specificities 1-10 were detected on LPS-stimulated splenic lymphocytes and on Con A-stimulated spleen, lymph node, and thymus blasts by direct cytotoxic tests. Since Ia antigens are not readily detectable on resting thymocytes, our results suggest that T cells require some signal before they exhibit full expression of Ia specificities. Absorption-elution studies indicated that most of the Ia specificities detected on T and B cells may be identical. Ia antigens detected by homologous antisera gave much stronger reactions than those detected by crossreacting antisera.
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U2 - 10.1084/jem.143.1.218
DO - 10.1084/jem.143.1.218
M3 - Article
C2 - 53267
AN - SCOPUS:0016870954
SN - 0022-1007
VL - 143
SP - 218
EP - 224
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 1
ER -