Exploring the Effect of Post-mastectomy complications on 5-year survival

Jacob B. Hammond, Ga ram Han, Patricia A. Cronin, Heide E. Kosiorek, Alanna M. Rebecca, William J. Casey, Erwin A. Kruger, Chad M. Teven, Barbara A. Pockaj

Research output: Contribution to journalArticlepeer-review


Background: Ramifications of postoperative complications on long-term survival after mastectomy are uncertain. Methods: Overall complications (Clavien-Dindo Grades I-IIIB) and wound complications were analyzed using the Kaplan-Meier method for impact on 5-year overall (OS) and disease-free survival (DFS). Results: A total of 378 patients underwent mastectomy alone (157, 41%) or mastectomy with reconstruction (221, 59%) for Stage I-III disease with a median follow-up of 5 years. Postoperative complications occurred in 186 patients (49%), requiring non-surgical (I/II = 83, 22%) or surgical (IIIa/IIIb = 103, 27%) management. Wound complications occurred in 140 patients (37%). Reconstruction was associated with a higher rate of complication (P < 0.001). Postoperative complications after mastectomy (with or without reconstruction) did not significantly affect OS or DFS. Wound complications also showed no significant effect on OS or DFS following mastectomy alone, or mastectomy with reconstruction. Conclusions: Postoperative complications after mastectomy, with or without reconstruction, bear no significant impact on 5-year survival.

Original languageEnglish (US)
Pages (from-to)1422-1427
Number of pages6
JournalAmerican journal of surgery
Issue number6
StatePublished - Dec 2020


  • Complications
  • Disease-free survival
  • Mastectomy
  • Overall survival
  • Reconstruction

ASJC Scopus subject areas

  • Surgery


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