TY - JOUR
T1 - Exploitation of host cell signaling machinery
T2 - Activation of macrophage phosphotyrosine phosphatases as a novel mechanism of molecular microbial pathogenesis
AU - Nandan, D.
AU - Knutson, K. L.
AU - Lo, R.
AU - Reiner, N. E.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Intracellular pathogens, particularly those that target host mononuclear phagocytes, have evolved strategies to either evade or inhibit cellular mechanisms of host defense. Mycobacterium tuberculosis and Leishmania donovani exemplify a diverse group of microorganisms that have developed the ability to invade and replicate within host macrophages, leading to disease expression. Recent studies have suggested that the pathogenesis of intracellular infection may involve interference with host cell signaling. Drawing upon examples from in vitro models that focused on M. tuberculosis and L. donovani, we review evidence that activation of host cell phosphotyrosine phosphatases may contribute to pathogenesis. A leading candidate appears to be the Src homology 2 domain containing phosphotyrosine phosphatase SHP-1, the activation of which may contribute to the development of infection and disease progression.
AB - Intracellular pathogens, particularly those that target host mononuclear phagocytes, have evolved strategies to either evade or inhibit cellular mechanisms of host defense. Mycobacterium tuberculosis and Leishmania donovani exemplify a diverse group of microorganisms that have developed the ability to invade and replicate within host macrophages, leading to disease expression. Recent studies have suggested that the pathogenesis of intracellular infection may involve interference with host cell signaling. Drawing upon examples from in vitro models that focused on M. tuberculosis and L. donovani, we review evidence that activation of host cell phosphotyrosine phosphatases may contribute to pathogenesis. A leading candidate appears to be the Src homology 2 domain containing phosphotyrosine phosphatase SHP-1, the activation of which may contribute to the development of infection and disease progression.
KW - Leishmania donovani
KW - Mycobacterium tuberculosis
KW - SHP-1
KW - Src
UR - http://www.scopus.com/inward/record.url?scp=0033840213&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033840213&partnerID=8YFLogxK
U2 - 10.1002/jlb.67.4.464
DO - 10.1002/jlb.67.4.464
M3 - Review article
C2 - 10770277
AN - SCOPUS:0033840213
SN - 0741-5400
VL - 67
SP - 464
EP - 470
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 4
ER -