ADJUVANT-induced arthritis in Rats shares many of the clinical and pathological features of human rheumatoid arthritis1. Cell-mediated immune mechanisms are believed to be of importance in the experimentally induced arthritis2. Although this experimental disease can be transferred by thoracic duct lymphocytes from sensitized to non-sensitized syngeneic recipient Rats3, it has been reported that neonatal thymectomy does not prevent subsequent induction of adjuvant arthritis4. We recently observed induction of adjuvant arthritis in Rats subjected to neonatal thymectomy, but not in sham thymectomized Rats. The accompanying finding that the severity of the arthritis was related to depression of an apparently thymus dependent antibody response may be a clue to the immunopathological mechanism involved in this arthritis model.
ASJC Scopus subject areas