Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence

Mikolaj Ogrodnik, Hanna Salmonowicz, Diana Jurk, João F. Passos

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Cellular senescence is a major driver of age-related diseases, and senotherapies are being tested in clinical trials. Despite its popularity, cellular senescence is weakly defined and is frequently referred to as irreversible cell-cycle arrest. In this article we hypothesize that cellular senescence is a phenotype that results from the coordination of two processes: cell expansion and cell-cycle arrest. We provide evidence for the compatibility of the proposed model with recent findings showing senescence in postmitotic tissues, wound healing, obesity, and development. We believe our model also explains why some characteristics of senescence can be found in non-senescent cells. Finally, we propose new avenues for research from our model.

Original languageEnglish (US)
Pages (from-to)996-1008
Number of pages13
JournalTrends in biochemical sciences
Issue number12
StatePublished - Dec 2019


  • aging
  • cellular senescence
  • obesity
  • theories of aging

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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