Exercise Counters the Age-Related Accumulation of Senescent Cells

Xu Zhang; Davis A. Englund; Zaira Aversa; Sarah K. Jachim; Thomas A. White; Nathan K. Lebrasseur

doi:10.1249/JES.0000000000000302

Exercise Counters the Age-Related Accumulation of Senescent Cells

Xu Zhang, Davis A. Englund, Zaira Aversa, Sarah K. Jachim, Thomas A. White, Nathan K. Lebrasseur

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

Abstract

We propose the beneficial effects of exercise are in part mediated through the prevention and elimination of senescent cells. Exercise counters multiple forms of age-related molecular damage that initiate the senescence program and activates immune cells responsible for senescent cell clearance. Preclinical and clinical evidence for exercise as a senescence-targeting therapy and areas needing further investigation are discussed.

Original language	English (US)
Pages (from-to)	213-221
Number of pages	9
Journal	Exercise and sport sciences reviews
Volume	50
Issue number	4
DOIs	https://doi.org/10.1249/JES.0000000000000302
State	Published - Oct 1 2022

Keywords

Aging
Geroscience
Healthspan
Senescence-associated secretory phenotype
Senotherapeutics

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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10.1249/JES.0000000000000302

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AU - White, Thomas A.

AU - Lebrasseur, Nathan K.

N1 - Publisher Copyright: © Lippincott Williams & Wilkins.

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AB - We propose the beneficial effects of exercise are in part mediated through the prevention and elimination of senescent cells. Exercise counters multiple forms of age-related molecular damage that initiate the senescence program and activates immune cells responsible for senescent cell clearance. Preclinical and clinical evidence for exercise as a senescence-targeting therapy and areas needing further investigation are discussed.

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KW - Geroscience

KW - Healthspan

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Exercise Counters the Age-Related Accumulation of Senescent Cells

Abstract

Keywords

ASJC Scopus subject areas

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