Exercise Counters the Age-Related Accumulation of Senescent Cells

Xu Zhang, Davis A. Englund, Zaira Aversa, Sarah K. Jachim, Thomas A. White, Nathan K. Lebrasseur

Research output: Contribution to journalArticlepeer-review


We propose the beneficial effects of exercise are in part mediated through the prevention and elimination of senescent cells. Exercise counters multiple forms of age-related molecular damage that initiate the senescence program and activates immune cells responsible for senescent cell clearance. Preclinical and clinical evidence for exercise as a senescence-targeting therapy and areas needing further investigation are discussed.

Original languageEnglish (US)
Pages (from-to)213-221
Number of pages9
JournalExercise and sport sciences reviews
Issue number4
StatePublished - Oct 1 2022


  • Aging
  • Geroscience
  • Healthspan
  • Senescence-associated secretory phenotype
  • Senotherapeutics

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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