TY - JOUR
T1 - Ex vivo evaluation of IVUS-VH imaging and the role of plaque structure on peripheral artery disease
AU - Noble, Christopher
AU - Carlson, Kent
AU - Neumann, Erica
AU - Lewis, Bradley
AU - Dragomir-Daescu, Dan
AU - Lerman, Amir
AU - Erdemir, Ahmet
AU - Young, Melissa
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020/12
Y1 - 2020/12
N2 - Peripheral artery disease (PAD) results from the buildup of atherosclerotic plaque in the arterial wall, can progress to severe ischemia and lead to tissue necrosis and limb amputation. We evaluated a means of assessing PAD mechanics ex vivo using ten human peripheral arteries with PAD. Pressure-inflation testing was performed at six physiological pressure intervals ranging from 10 to 200 mmHg. These vessels were imaged with IVUS-VH to determine plaque composition and change in vessel structure with pressure. Statistical analysis was performed to determine which plaque structures and distributions of these structures had the greatest influence on wall deformation. We found that fibrous plaque, necrotic core, and calcification had a statistically significant effect on all variables (p < 0.05). The presence of large concentrations of fibrous plaque was linked to reduced vessel compliance and ellipticity, which could lead to stent fractures and restenosis. For the plaque distribution we found that clustered necrotic core increased overall compliance while clustered calcification decreased overall compliance. The effect of plaque distribution on vessel wall deformation must be considered equally important to plaque concentration.
AB - Peripheral artery disease (PAD) results from the buildup of atherosclerotic plaque in the arterial wall, can progress to severe ischemia and lead to tissue necrosis and limb amputation. We evaluated a means of assessing PAD mechanics ex vivo using ten human peripheral arteries with PAD. Pressure-inflation testing was performed at six physiological pressure intervals ranging from 10 to 200 mmHg. These vessels were imaged with IVUS-VH to determine plaque composition and change in vessel structure with pressure. Statistical analysis was performed to determine which plaque structures and distributions of these structures had the greatest influence on wall deformation. We found that fibrous plaque, necrotic core, and calcification had a statistically significant effect on all variables (p < 0.05). The presence of large concentrations of fibrous plaque was linked to reduced vessel compliance and ellipticity, which could lead to stent fractures and restenosis. For the plaque distribution we found that clustered necrotic core increased overall compliance while clustered calcification decreased overall compliance. The effect of plaque distribution on vessel wall deformation must be considered equally important to plaque concentration.
KW - Atherosclerosis
KW - Intrasvascular ultrasound
KW - Peripheral artery disease
KW - Pressure-inflation testing
KW - Virtual histology
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U2 - 10.1016/j.medntd.2020.100042
DO - 10.1016/j.medntd.2020.100042
M3 - Article
AN - SCOPUS:85114075072
SN - 2590-0935
VL - 8
JO - Medicine in Novel Technology and Devices
JF - Medicine in Novel Technology and Devices
M1 - 100042
ER -