Evidenced-Based Screening Strategies for a Positive Family History

Jennifer M. Kolb, Dennis J. Ahnen, N. Jewel Samadder

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The most commonly recognized high-risk group for colorectal cancer (CRC) is individuals with a positive family history. It is generally recognized that those with a first-degree relative (FDR) with CRC are at a 2-fold or higher risk of CRC or advanced neoplasia. FDRs of patients with advanced adenomas have a similarly increased risk. Accordingly, all major US guidelines recommend starting CRC screening by age 40 in these groups. Barriers to screening this group include patient lack of knowledge on family and polyp history, provider limitations in collecting family history, and insufficient application of guidelines.

Original languageEnglish (US)
Pages (from-to)597-609
Number of pages13
JournalGastrointestinal Endoscopy Clinics of North America
Issue number3
StatePublished - Jul 2020


  • Advanced adenoma
  • Colon cancer screening
  • Colorectal cancer
  • First-degree relative
  • Second-degree relative

ASJC Scopus subject areas

  • Gastroenterology


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