Evidence of linkage disequilibrium in the Spanish polycystic kidney disease I population

Belén Peral, Christopher J. Ward, José L. San Millán, Sandra Thomas, Raymond L. Stallings, Felipe Moreno, Peter C. Harris

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56 Scopus citations


Forty-one Spanish families with polycystic kidney disease 1 (PKD1) were studied for evidence of linkage disequilibrium between the disease locus and six closely linked markers. Four of these loci-three highly polymorphic microsatellites (SM6, CW3, and CW2) and an RFLP marker (Blu24)-are described for the first time in this report. Overall the results reveal many different haplotypes on the disease-carrying chromosome, suggesting a variety of independent PKD1 mutations. However, linkage disequilibrium was found between BLu24 and PKD1, and this was corroborated by haplotype analysis including the microsatellite polymorphisms. From this analysis a group of closely related haplotypes, consisting of four markers, was found on 40% of PKD1 chromosomes, although markers flanking this homogeneous region showed greater variability. This study has highlighted an interesting subpopulation of Spanish PKD1 chromosomes, many of which have a common origin, that may be useful for localizing the PKD1 locus more precisely.

Original languageEnglish (US)
Pages (from-to)899-908
Number of pages10
JournalAmerican journal of human genetics
Issue number5
StatePublished - May 17 1994

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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