Evidence-based medicine: Application in Alzheimer's disease research

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The two fundamental principles of evidence-based medicine indicate that a hierarchy of evidence exists and that evidence alone is never sufficient to make clinical decisions. Incorporation of factors other than evidence such as patients' values and preferences, clinical context, and resource allocation are essential factors for decision making. The knowledge of these principles orients the use of clinical care research by evidence users such as patients, clinicians, and policy makers; and also helps researchers create research protocols and agendas that produce evidence that fulfills the needs of these users. Examples of research in Alzheimer's disease are presented to illustrate how evidence is produced, appraised and utilized.

Original languageEnglish (US)
Pages (from-to)935-942
Number of pages8
JournalJournal of Alzheimer's Disease
Issue number3
StatePublished - 2010


  • Alzheimer's disease
  • evidence-based medicine
  • patients' values and preferences
  • quality of evidence
  • research methodology

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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