TY - JOUR
T1 - Evaluation of pulsatile patterns of growth hormone release in humans
T2 - A brief review
AU - Hartman, Mark L.
AU - Iranmanesh, Ali
AU - Thorner, Michael O.
AU - Veldhuis, Johannes D.
PY - 1993
Y1 - 1993
N2 - Growth hormone (GH) is an important metabolic hormone, which stimulates net protein anabolism, lipolysis, and linear bone growth. Pulses of GH secretion arise from interactions of hypothalamic GH‐releasing hormone and somatostatin at the somatotroph cell in the anterior pituitary gland. The frequency and amplitude of GH pulses are regulated by multiple factors including age, geneder, pubertal status, menstrual cycle phase, body composition, sleep, nutrition, and exercise. In diseases such as obesity, type I diabetes mellitus, hypo‐ and hyperthyroidism, Turner's syndrome, uremia, liver failure, and acromegaly the pulsatile secretion of GH and/or its metabolic clearance rate are altered. Deconvolution analysis of serum GH concentrations measured in blood obtained at frequent intervals has made it possible to simultaneously resolve subject‐specific metabolic clearance rates and the number, amplitude, duration, and mass of GH secretory bursts. Such analyses have provided new insights into the mechanisms regulating pulsatile patterns of GH release in human health and disease. © 1993 Wiley‐Liss, Inc.
AB - Growth hormone (GH) is an important metabolic hormone, which stimulates net protein anabolism, lipolysis, and linear bone growth. Pulses of GH secretion arise from interactions of hypothalamic GH‐releasing hormone and somatostatin at the somatotroph cell in the anterior pituitary gland. The frequency and amplitude of GH pulses are regulated by multiple factors including age, geneder, pubertal status, menstrual cycle phase, body composition, sleep, nutrition, and exercise. In diseases such as obesity, type I diabetes mellitus, hypo‐ and hyperthyroidism, Turner's syndrome, uremia, liver failure, and acromegaly the pulsatile secretion of GH and/or its metabolic clearance rate are altered. Deconvolution analysis of serum GH concentrations measured in blood obtained at frequent intervals has made it possible to simultaneously resolve subject‐specific metabolic clearance rates and the number, amplitude, duration, and mass of GH secretory bursts. Such analyses have provided new insights into the mechanisms regulating pulsatile patterns of GH release in human health and disease. © 1993 Wiley‐Liss, Inc.
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U2 - 10.1002/ajhb.1310050603
DO - 10.1002/ajhb.1310050603
M3 - Article
AN - SCOPUS:84995256367
SN - 1042-0533
VL - 5
SP - 603
EP - 614
JO - American Journal of Human Biology
JF - American Journal of Human Biology
IS - 6
ER -